{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:48:15Z","timestamp":1782978495947,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012566","name":"Health System Independent Innovation Science Foundation of Shanghai Putuo District","doi-asserted-by":"publisher","award":["2023ysxk01"],"award-info":[{"award-number":["2023ysxk01"]}],"id":[{"id":"10.13039\/501100012566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240309"],"award-info":[{"award-number":["202240309"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study is aimed at examining the associations between insulin resistance (IR) surrogate indices, including TyG, TyG\u2010BMI, TG\/HDL\u2010C, and METS\u2010IR, and hyperuricemia (HUA) in young and middle\u2010aged patients with Type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1005 patients with T2DM were included in this cross\u2010sectional study. Participants were classified into HUA and nonhyperuricemia (NHUA) groups according to serum uric acid concentrations and further stratified by age into young (18\u201344 years) and middle\u2010aged (45\u201359 years) subgroups. Multivariable logistic regression analyses were performed to assess the associations between IR surrogate indices and HUA. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the discriminatory ability of these indices for HUA across sex\u2010 and age\u2010specific subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All IR surrogate indices were significantly higher in the HUA group than in the NHUA group. TyG and TG\/HDL\u2010C showed stable associations with HUA across the regression models, while the association for TyG\u2010BMI was attenuated after additional adjustment when modeled continuously, although individuals in the highest quartile remained associated with higher odds of HUA. METS\u2010IR was associated with HUA only in unadjusted models. Age\u2010stratified analyses showed that none of the IR surrogate indices remained significantly associated with HUA after multivariable adjustment in younger patients, whereas TyG and TG\/HDL\u2010C remained associated with higher odds of HUA in middle\u2010aged patients. ROC analyses indicated limited to moderate discriminatory performance (AUC\u2009&lt;\u20090.75). TyG\u2010BMI showed the highest AUC in younger patients (AUC = 0.715), while TG\/HDL\u2010C demonstrated relatively higher specificity in middle\u2010aged patients. Sex\u2010stratified analyses showed slightly higher AUC values in males than in females, although overall discrimination remained modest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IR surrogate indices showed varying associations with HUA in young and middle\u2010aged patients with Type 2 diabetes. TyG and TG\/HDL\u2010C showed relatively stable associations with HUA across the regression models, whereas the associations for TyG\u2010BMI and METS\u2010IR were attenuated after additional adjustment. Overall, these indices demonstrated limited discriminatory performance and are not suitable as standalone diagnostic tools but may serve as adjunctive markers for preliminary risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/6682372","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:18:35Z","timestamp":1782976715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between a Surrogate Index of Insulin Resistance and Hyperuricemia in Young and Middle\u2010Aged Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2026","author":[{"given":"Hongping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-2901","authenticated-orcid":false,"given":"Yunyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-2219","authenticated-orcid":false,"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-5113","authenticated-orcid":false,"given":"Tao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8884-6291","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-2354","authenticated-orcid":false,"given":"Zongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.087"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.04.008"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0115-y"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.056"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190408122557"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102271"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11172460"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S363429"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00098"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179221"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13006"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/762820"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.008"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-111"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173089"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90106-2"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.101430"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41779"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0589-4"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.22-63"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149731"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01625-2"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02334-8"},{"key":"e_1_2_13_27_2","first-page":"482","article-title":"Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 Edition), (in Chinese)","volume":"41","author":"Branch C. 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