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Conventional Western medicine has limitations in efficacy and safety in managing complications, while acupuncture, with multitarget regulation and low side effects, serves as an important supplementary therapy. This review discusses how acupuncture relieves macrovascular complications, such as angina and cerebral reperfusion, by inhibiting NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B, improving vascular endothelial function, and regulating autonomic nerves. In addition, acupuncture delays microvascular complications, such as retinopathy and proteinuria via vasodilation, anti\u2010inflammatory effects, antioxidative effects, and neurotrophic promotion. Acupuncture also benefits other complications by enhancing microcirculation and neuroendocrine function. The mechanisms of acupuncture involve regulating the metabolic\u2010inflammatory\u2010neurovascular network, activating pathways (such as GLP\u20101 and SDF\u20101), and repairing cellular structures. Modern technologies\u2014including artificial intelligence (AI) for individualized acupoint selection, functional magnetic resonance imaging (fMRI) for central regulation visualization, and biomaterial combination for diabetic foot repair\u2014enhance the precision of acupuncture. However, clinical translation of acupuncture faces the following challenges: fragmented mechanisms; insufficient clinical evidence, including small samples, short follow\u2010ups, and a lack of long\u2010term safety data when used with new hypoglycemics; and technical nonstandardization, such as inconsistent acupoint selection, nonuniform operation parameters, and poor adaptability of AI to traditional Chinese medicine syndrome differentiation. Future research should deepen the exploration of the neuroendocrine\u2013immune network via interdisciplinary integration, conducting large\u2010sample long\u2010term trials, establishing standardized protocols, and validating AI\/fMRI\u2010assisted precision acupoint selection to accelerate the transition of acupuncture from adjuvant to precision therapy to improve patients\u2019 quality of life.\n                  <\/jats:p>","DOI":"10.1155\/jdr\/6934081","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:50:07Z","timestamp":1758534607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of Acupuncture in Diabetic Vascular Complications: Efficacy and Potential 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