{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:03:01Z","timestamp":1780034581751,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":147,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We are aimed at evaluating the effects of a calorie\u2010restricted low\u2010carbohydrate diet (CR\u2010LCD) on diabetes remission, weight control, and metabolic parameters in overweight patients with early\u2010stage Type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>\n                      This 6\u2010month randomized intervention trial with a 12\u2010month follow\u2010up randomly assigned 68 adults with early\u2010stage T2DM to receive either a CR\u2010LCD or a control diet. Of the original cohort, data from 66 participants (two dropouts in the CR\u2010LCD group) were analyzed. The primary outcome was diabetes remission, defined as achieving a glycated\u2009hemoglobin\u2009(HbA1c)\u2009level &lt; 6.5\n                      <jats:italic>%<\/jats:italic>\n                      without glucose\u2010lowering medications; secondary outcomes included anthropometric, glycemic, and lipid parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CR\u2010LCD group had a significantly higher 6\u2010month diabetes remission rate than the control group (62.50% vs. 35.29%,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 4.885,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027). After multivariate adjustment, the intervention was associated with higher remission rates (odds\u2009ratio\u2009[OR] = 4.592, 95% confidence interval [CI]: 1.276\u201316.524;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020). At 12 months, between\u2010group comparisons following false discovery rate (FDR) correction revealed significant differences in body mass index (FDR \u2212 adjusted\u2009\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.150), waist circumference (FDR \u2212 adjusted\u2009\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.085), fasting blood glucose (FDR \u2212 adjusted\u2009\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001,\n                      <jats:italic>r<\/jats:italic>\n                      = 0.613), 2\u2010h postprandial blood glucose (FDR \u2212 adjusted\u2009\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.088), and high\u2010density lipoprotein cholesterol (FDR \u2212 adjusted\u2009\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.095). No severe adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A CR\u2010LCD was effective in inducing diabetes remission in early\u2010stage T2DM, suggesting that it may offer a viable nonpharmacological management strategy for this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2600118189.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/7230214","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:37:48Z","timestamp":1780033068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Achieving Diabetes Remission Through Dietary Intervention: A 12\u2010Month Randomized Controlled Trial of Caloric\u2010Carbohydrate Restriction in Overweight Patients With Early\u2010Stage Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2026","author":[{"given":"Hongquan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-8398","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-4316","authenticated-orcid":false,"given":"Yanyao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01951-9"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2860"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1298101"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33102-1"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30117-0"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-024-01657-9"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040991"},{"key":"#cr-split#-e_1_2_11_8_2.1","doi-asserted-by":"crossref","unstructured":"(a) Taylor R Al-Mrabeh A Sattar N. 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