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Breathomics, the investigation of exhaled volatile organic compounds (VOCs), offers a promising approach for evaluating glycemic control, oxidative stress, and metabolic alterations associated with diabetes. Specific VOCs, such as acetone, isoprene, and ethanol, reflect glucose fluctuations, lipid oxidation, and insulin sensitivity, linking metabolic changes to real\u2010time physiological states. Recent analytical advancements in gas chromatography\u2013mass spectrometry, proton transfer reaction\u2013mass spectrometry, and electronic nose technologies have enhanced the reliability and clinical applicability of breath\u2010based assessments. The investigations focus on integrating VOC\u2010based metabolic signatures with lifestyle and behavioral factors to establish a precision, noninvasive framework for diabetes management. This review also discusses key challenges that remain in standardizing breath analysis techniques, interpreting complex breath data, and implementing breath\u2010based technology into personalized diabetes management. 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