{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:18:14Z","timestamp":1787908694509,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":239,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) commonly affects patients with Type 2 diabetes mellitus (T2DM). Fibrosis\u20104 (FIB\u20104) has been linked to chronic kidney disease (CKD) in patients with MASLD; however, its association with CKD in broader, not preselected for MASLD, T2DM populations remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association of FIB\u20104 with CKD in unselected patients with T2DM and compare its discriminatory ability with that of HellenicSCORE II and aspartate aminotransferase\u2010to\u2010platelet ratio index (APRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed data from consecutive patients with T2DM. Characteristics and baseline laboratory results were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 214 patients (mean age 67.6 \u00b1 10.3 years) were enrolled, including 158 (73.8%) males and 56 (26.2%) females. Ninety\u2010six (44.8%) had normal kidney function, and 54 (25.2%) had CKD at enrollment. Those with CKD were significantly older (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and had higher scores on the HellenicSCORE II (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), APRI (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), and FIB\u20104 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Additionally, hypertension and cardiovascular disease were more common in the CKD than in the non\u2010CKD group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001 for both). In the multivariate analysis, sex (OR: 0.13, 95% CI: 0.03\u20130.6;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008) and FIB\u20104 (OR: 10.4, 95% CI: 2\u201354.1;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) were independently associated with CKD. Among the evaluated scores, FIB\u20104 demonstrated the highest numerical AUROC for identifying CKD (0.769; 95% CI: 0.668\u20130.869), compared with APRI (0.668; 95% CI: 0.558\u20130.778) and HellenicSCORE II (0.651; 95% CI: 0.544\u20130.757).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FIB\u20104 was independently associated with the presence of CKD in patients with T2DM and demonstrated the highest numerical AUROC among the evaluated scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/8029869","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:23:20Z","timestamp":1787905400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of FIB\u20104, APRI, and HellenicSCORE II With Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6573-3552","authenticated-orcid":false,"given":"Katerina","family":"Stefanaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-634X","authenticated-orcid":false,"given":"Dimitrios S.","family":"Karagiannakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Manolakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5855-0393","authenticated-orcid":false,"given":"Stefania","family":"Magkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-5577","authenticated-orcid":false,"given":"Paraskevi","family":"Kazakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Zacharaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-2534","authenticated-orcid":false,"given":"Melpomeni","family":"Peppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-2297","authenticated-orcid":false,"given":"Evanthia","family":"Kassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-9716","authenticated-orcid":false,"given":"Theodora","family":"Psaltopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-1376","authenticated-orcid":false,"given":"Stavroula A.","family":"Paschou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"IDF Diabetes Atlas","author":"International Diabetes 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