{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:05:34Z","timestamp":1774566334481,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    GLP\u20101 receptor agonists (GLP\u20101RAs) are extensively used in treating Type 2 diabetes due to their therapeutic benefits. However, clinical reports have highlighted adverse events, particularly the underexplored association with tumor development. This study investigates GLP\u20101RA\u2013related adverse events, focusing on tumorigenic risks, using data from the FDA Adverse Event Reporting System (FAERS). FAERS data from Q1 2005 to Q4 2023 were analyzed using the proportional reporting ratio (PRR) method to identify GLP\u20101RA\u2013associated adverse events. Detailed analyses examined event distribution across genders, ages, and body weights, with an emphasis on tumor\u2010related risks in vulnerable subpopulations. A total of 195,250 GLP\u20101RA\u2013related adverse event reports were identified, spanning 25 system organ classes (SOCs). The most reported SOCs were gastrointestinal disorders (\n                    <jats:italic>n<\/jats:italic>\n                    = 110,451, PRR 2.44), investigative findings (\n                    <jats:italic>n<\/jats:italic>\n                    = 80,126, PRR 2.46), and metabolism and nutrition disorders (\n                    <jats:italic>n<\/jats:italic>\n                    = 25,236, PRR 2.21). Notably, 7457 cases involved benign, malignant, and unspecified tumors (PRR 0.5). Further analysis revealed that the risk of GLP\u20101RA\u2013associated tumorigenesis varied by age, sex, and weight, suggesting that tumorigenesis risk differed in specific subpopulations. These findings underscore the need for vigilance regarding GLP\u20101RA\u2013related adverse events, particularly tumor risks in specific subgroups. Clinicians should consider patient\u2010specific factors, such as age, gender, and body weight, to ensure safe and effective GLP\u20101RAs therapy.\n                  <\/jats:p>","DOI":"10.1155\/jdr\/8893769","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:42:07Z","timestamp":1774032127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety Assessment of Glucagon\u2010Like Peptide 1 Receptor Agonists Based on the FAERS Database: Focus on Tumorigenic Risk in 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