{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:26:12Z","timestamp":1791563172441,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to explore the effect of bedside normobaric saturated oxygen inhalation combined with upper and lower limb rehabilitation training on diabetic lower extremity arterial disease (LEAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From January 2022 to December 2023, 60 DM\u2010LEAD patients from the Second Hospital of Hebei Medical University were randomly divided into control (30 cases) and study (30 cases) groups. Both received standard treatment; the control group added MOTOmed\u2010based limb rehabilitation training, and the study group further received atmospheric saturated oxygen therapy. Pre\u2010 and posttreatment indices (VAS, Barthel index, blood glucose, blood lipid, inflammatory factors, ABI, TcPO\n                      <jats:sub>2<\/jats:sub>\n                      , and DPA flow velocity) were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups improved posttreatment (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), with the study group showing greater benefits (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05): VAS decreased more (3.82 \u00b1 0.75 vs. 2.15 \u00b1 0.62 points), Barthel index increased more (28.67 \u00b1 4.21 vs. 15.33 \u00b1 3.85 points), FBG (2.35 \u00b1 0.52 vs. 1.21 \u00b1 0.45\u2009mmol\/L) and 2hPBG (3.12 \u00b1 0.68 vs. 1.78 \u00b1 0.59\u2009mmol\/L) decreased more, IL\u20106 (8.76 \u00b1 1.52 vs. 4.23 \u00b1 1.18\u2009pg\/mL) and CRP (12.35 \u00b1 2.18 vs. 6.12 \u00b1 1.85\u2009mg\/L) decreased more, and ABI (0.38 \u00b1 0.07 vs. 0.20 \u00b1 0.06), TcPO\n                      <jats:sub>2<\/jats:sub>\n                      (18.67 \u00b1 3.25 vs. 9.35 \u00b1 2.78\u2009mmHg), and DPA flow velocity (0.18 \u00b1 0.04 vs. 0.09 \u00b1 0.03\u2009m\/s) increased more.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined therapy improves pain and daily living abilities, delays DM\u2010LEAD progression, may reduce amputation risk, and improves outcomes. Long\u2010term effects need further study.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      The UK\u2032s Clinical Study Registry: ISRCTN11014449\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/9121093","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:00:38Z","timestamp":1768377638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Atmospheric Saturated Oxygen Combined With Intelligent Upper and Lower Limb Rehabilitation Training on Diabetic Lower Extremity Arterial Disease"],"prefix":"10.1155","volume":"2026","author":[{"given":"Zi-Bo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Xiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-8701","authenticated-orcid":false,"given":"Hong-Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319880044"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.10.003"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2011.00171.x"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.012"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.31662\/jmaj.2021-0042"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13724"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa095"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620954066"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2022.09.006"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221149786"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2256"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081210"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.07.047"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102352"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061509"},{"key":"e_1_2_14_17_2","first-page":"176","article-title":"Essentials of Hyperbaric Oxygen Therapy: 2019 Review","volume":"116","author":"Kirby J. 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