{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:29:20Z","timestamp":1789576160558,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between albumin\u2010corrected fructosamine (AlbF) levels and the presence of diabetic retinopathy (DR) in adults with Type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study retrospectively analyzed 1263 inpatients with T2DM. After applying exclusion criteria, 415 patients were included and categorized into DR (\n                      <jats:italic>n<\/jats:italic>\n                      = 174) and non\u2010DR (\n                      <jats:italic>n<\/jats:italic>\n                      = 241) groups based on fundus examination. The association between the AlbF\u2014analyzed both continuously (per 10\u2009\n                      <jats:italic>\u03bc<\/jats:italic>\n                      mol\/g increment) and categorically (by tertiles)\u2014and DR was assessed using multivariable logistic regression with progressive adjustment for sociodemographic, clinical, and laboratory confounders. Supplementary analyses, including receiver operating characteristic (ROC) curve assessment and interaction testing across predefined subgroups, evaluated the association\u2032s robustness and consistency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of DR was 41.9%. Following full adjustment, each 10\u2009\n                      <jats:italic>\u03bc<\/jats:italic>\n                      mol\/g increment in AlbF was associated with higher odds of having DR (adjusted OR = 1.88, 95% CI: 1.36\u20132.60;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). A significant dose\u2013response relationship was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009for\u2009trend &lt; 0.001), with patients in the highest AlbF tertile exhibiting 7.20 times the odds of DR (95% CI: 2.82\u201318.40) compared to the lowest tertile. Furthermore, the association remained consistent across all predefined subgroups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009for\u2009interaction &gt; 0.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated AlbF was independently associated with the presence of DR in adults with T2DM, demonstrating a significant dose\u2013response relationship. AlbF shows promise as a biomarker candidate for DR identification and stratification. Its potential clinical utility requires validation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jdr\/9275699","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:41:10Z","timestamp":1770100870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Study of the Relationship Between Serum Albumin\u2013Corrected Fructosamine and Type 2 Diabetic Retinopathy"],"prefix":"10.1155","volume":"2026","author":[{"given":"Zejiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-9430","authenticated-orcid":false,"given":"Qiyun","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7286-0149","authenticated-orcid":false,"given":"Xuhui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0816-7473","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3393-4284","authenticated-orcid":false,"given":"Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108072"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.07.031"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05516-w"},{"key":"e_1_2_14_5_2","first-page":"69","article-title":"Fructosamine as a Parameter for Monitoring Carbohydrate Metabolism in the Treatment of Diabetes Mellitus","volume":"180","author":"Rotmann D.","year":"1990","journal-title":"Wiener Klinische Wochenschrift. 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