{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:22:23Z","timestamp":1780460543494,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":91,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Hyperlipidemia is a major, modifiable driver of global cardiovascular risk. The intestinal microbiota, comprising bacteria, archaea, fungi, and viruses, modulates lipid metabolism through bile acid transformation, energy harvest, and inflammatory signaling. This study profiled the gut microbiota of 15 adults with type 2 diabetes mellitus (T2DM) and explored associations with fasting lipid measures using 16S rRNA gene sequencing (V3\u2013V4 region) on the Illumina MiSeq platform and PICRUSt2 functional prediction. Overall \u03b1\u2010diversity was reduced, and community composition was dominated by Firmicutes and Actinobacteria with relative depletion of Bacteroidetes. At lower taxonomic ranks, enrichment of\n                    <jats:italic>Prevotella copri<\/jats:italic>\n                    ,\n                    <jats:italic>Collinsella<\/jats:italic>\n                    spp.,\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    spp., and selected\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    spp. was observed, alongside depletion of short\u2010chain fatty acid (SCFA)\u2010linked taxa, including\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    , and members of the\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    and\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    lineages. Exploratory within\u2010cohort trends indicated that higher triglycerides (TGs) and lower HDL\u2010C tended to co\u2010occur with increased\n                    <jats:italic>Collinsella<\/jats:italic>\n                    and clostridial signals and reduced SCFA\u2010associated taxa. Predicted Kyoto Encyclopedia of Genes and Genomes (KEGG) ortholog functions suggested shifts in lipid, carbohydrate, and secondary bile acid metabolism, consistent with a metabolically activated and proinflammatory intestinal milieu. In this single\u2010arm cohort of adults with T2DM, a low\u2010diversity, Firmicutes\/Actinobacteria\u2010weighted microbiome with depletion of SCFA\u2010linked taxa paralleled an atherogenic lipid profile, supporting an association between gut microbial dysbiosis and lipid abnormalities in adults with T2DM. These findings suggest the potential of microbiota\u2010informed adjuncts, including dietary fermentable fiber, targeted probiotics and next\u2010generation biotherapeutics, and bile\u2010acid\u2010modulating strategies as supportive approaches to lipid management in T2DM. This was a pilot, single\u2010arm, exploratory study without a nondiabetic control group, and findings should be interpreted as hypothesis\u2010generating. Nevertheless, the cross\u2010sectional design, small sample size, and 16S\u2010based taxonomic resolution limit causal interpretation. Larger, longitudinal studies integrating shotgun metagenomics and metabolomics are needed to confirm these associations, validate biomarkers, and elucidate mechanistic pathways that could guide precision interventions for diabetic dyslipidemia.\n                  <\/jats:p>","DOI":"10.1155\/jdr\/9317962","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:50:42Z","timestamp":1775116242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut Microbiota and Dyslipidemia in Type 2 Diabetes: A Pilot Study of 16S rRNA Profiles and Predicted Functional Shifts"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4102-2279","authenticated-orcid":false,"given":"Godfred Antony","family":"Menezes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadharshini","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areebah","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketaki Devendra","family":"Tayade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Fathima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaina Falak Zahir","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071613"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2500102"},{"key":"e_1_2_13_3_2","unstructured":"World Health Organization Cardiovascular Diseases (CVDs) 2025 World Health Organization https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122227"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1408581"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i30.108680"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1520252"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1333145"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107694"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04440-22"},{"key":"e_1_2_13_11_2","unstructured":"Cleveland Clinic Lipid Panel 2025 Cleveland Clinic https:\/\/my.clevelandclinic.org\/health\/diagnostics\/17176-lipid-panel."},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks808"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/1942268"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky962"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306807"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18646"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2340487"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.886902"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2266"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00900-1"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308778"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1984104"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.104638"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/9317962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jdr\/9317962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jdr\/9317962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:50:47Z","timestamp":1775116247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jdr\/9317962"}},"subtitle":[],"editor":[{"given":"Saisai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jdr\/9317962"],"URL":"https:\/\/doi.org\/10.1155\/jdr\/9317962","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9317962"}}