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Dampening neutrophil activity may therefore be a means of preventing acute and chronic inflammatory diseases; however, little is known about potential drugs to modulate neutrophil activity. 4\u2010Phenyl butyric acid (4\u2010PBA) is a clinically used drug, which acts as a chemical chaperone to inhibit endoplasmic reticulum (ER) stress and to suppress immune activation. Here, we investigated the potential of 4\u2010PBA to regulate neutrophil\u2010mediated inflammation and specifically the recruitment cascade of neutrophils. We found that 4\u2010PBA suppressed perinatal neutrophil recruitment cascade as assessed by fetal intravital microscopy (IVM), as well as transmigration of neutrophils through the endothelial compartment via the inositol\u2010requiring enzyme (IRE)\u20101\u03b1\/extracellular signal\u2010regulated kinase (ERK) 1\/2 signaling pathway. Likewise, 4\u2010PBA promoted an anti\u2010inflammatory phenotype by suppressing the release of pro\u2010inflammatory mediators in bone marrow neutrophils and endothelial cells in vitro. Taken together, our data indicate that 4\u2010PBA can exert anti\u2010inflammatory effects by limiting excessive neutrophil infiltration into inflamed tissues, thereby holding significant therapeutic potential in managing various inflammatory diseases.<\/jats:p>","DOI":"10.1155\/jimr\/2438058","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T01:34:03Z","timestamp":1751938443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["4\u2010Phenyl Butyric Acid (4\u2010PBA) Suppresses Neutrophil Recruitment in a Murine Model of Acute Perinatal 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