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These enzymes exhibit diverse tissue distributions with different activation mechanisms involved. They play vital roles in several physiological processes, such as defense against pathogens, wound healing, regulation of gene expression, post\u2010translational modification of proteins, cell signaling, and cell differentiation. The present review highlights an indispensable role of NOX expression and resulting ROS production on various biological processes, specifically focusing on cell differentiation at various stages of embryonic development and differentiation of monocytes to macrophages within the mononuclear phagocytic system. It also discusses the influence of altered expression of NOX isoforms on the fate of macrophage polarization either towards pro\u2010inflammatory (M1) or anti\u2010inflammatory (M2) macrophages. 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