{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:52:58Z","timestamp":1791899578430,"version":"4.3.4"},"reference-count":123,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":361,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274576"],"award-info":[{"award-number":["82274576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205179"],"award-info":[{"award-number":["82205179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Asthma is a chronic inflammatory respiratory disease with a distinct circadian rhythm. Common symptoms like cough, wheezing, and dyspnea, are worse at night and in the early morning (around 4 a.m.). The circadian pattern of asthma is intrinsically connected to the body\u2019s internal clock, which regulates a wide range of biological processes via transcription\u2010translation feedback loop (TTFL). BMAL1 and CLOCK play a central role in the regulatory networks that control metabolism and immune function. When circadian rhythms are disrupted, it can result in metabolic disorders, immune dysfunction, and a worsening of asthma symptoms. A deeper understanding of the mechanisms underlying circadian rhythms may pave the way for innovative asthma treatments. Furthermore, the exploration and application of natural drugs and targeted therapies focusing on circadian rhythm genes show potential as a key approach for future precision treatment of asthma.<\/jats:p>","DOI":"10.1155\/jimr\/3246881","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:16:18Z","timestamp":1766985378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Circadian Rhythm of Asthma Immune Metabolism"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6411-6630","authenticated-orcid":false,"given":"Manchen","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9050-0598","authenticated-orcid":false,"given":"Feiyan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5626-9964","authenticated-orcid":false,"given":"Xiaoman","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1802-1341","authenticated-orcid":false,"given":"Zhuiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4513-1431","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4505-4869","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5959-652X","authenticated-orcid":false,"given":"Shengyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0880-6386","authenticated-orcid":false,"given":"Xinguang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-1425","authenticated-orcid":false,"given":"Yazun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-4450","authenticated-orcid":false,"given":"Wenbo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-1050","authenticated-orcid":false,"given":"Zheng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0217-5"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00170"},{"key":"e_1_2_13_4_2","unstructured":"Global Initiative for Asthma (GINA) Global Strategy for Asthma Management and Prevention [Internet] 2006 https:\/\/ginasthma.org\/ Accessed on: Date last updated 2006."},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.05.001"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.005"},{"key":"e_1_2_13_7_2","first-page":"123","volume-title":"Allergy Essentials","author":"O\u2019Hehir R. E.","year":"2022"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12010010"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2024.16.1.1"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8712-1"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2032506"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3049"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.016"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2232PP"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608969"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328011b84b"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.10.002"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6491-0"},{"key":"e_1_2_13_19_2","first-page":"1401","article-title":"Occupational Asthma","volume":"45","author":"Wills M. C.","year":"1999","journal-title":"Canadian Family Physician Medecin De Famille Canadien"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2024.1607640"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2023-001943"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.10.006"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74883-7"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13185492"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310647"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2024.2414931"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74297-5"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.10.026"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_241_17"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102168"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/07487304241273182"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12091961"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.13.612486"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.150"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196766"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00679-8"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1516279"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12696"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icab017"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/23727322231193967"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30815"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2024.3471254"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302233RR"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00905-5"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01859-0"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2024.111852"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00152.2015"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203482"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41606-017-0019-2"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6833.998"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypdi.2012.02.004"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02407-2019"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1640731"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215218"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03245-w"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018486118"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13508"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2018.10.014"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22834-5"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221094"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom13060893"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051178"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01021-0"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08773-6"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP284686"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1149203"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041231"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01619-2023"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060656"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.2001.0319"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.066"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.11.012"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00377.2014"},{"key":"e_1_2_13_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175880"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.6_supplement.137s"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2021.1938595"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947067"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-006-0017-0"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.5.1153"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153128"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748730405277232"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2023.03.004"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.017"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0638"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.237081.113"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.01.019"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.3.512"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9911107"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3_suppl.399S"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.004"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.04.002"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S302508"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2020.215"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00072.2017"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01057-9"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.16122"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000830"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3599"},{"key":"e_1_2_13_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113947"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00302-6"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2013-0049"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.004"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2018.09.001"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.15698\/cst2020.01.209"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00075"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2023.2203841"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034602"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.11"},{"key":"e_1_2_13_109_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106750109"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5539"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20240064"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804092"},{"key":"e_1_2_13_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00499-w"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.2253"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.03.007"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.1159\/000375452"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.019"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113773"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01743"},{"key":"e_1_2_13_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.019"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600353R"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25170"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.070"}],"updated-by":[{"DOI":"10.1155\/jimr\/9801216","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000}}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/3246881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jimr\/3246881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/3246881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:30:09Z","timestamp":1776789009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jimr\/3246881"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh Prabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":123,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/jimr\/3246881"],"URL":"https:\/\/doi.org\/10.1155\/jimr\/3246881","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3246881"}}