{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:51Z","timestamp":1792140351225,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":288,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700601"],"award-info":[{"award-number":["2021YFC2700601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Although hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is a key regulator in cancer biology, the mechanism by which the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing enzyme cystathionine\u2010\u03b3\u2010lyase (CTH) functions in hepatocellular carcinoma (HCC) remains elusive. Using the slow\u2010releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor GYY4137, we observed enhanced migration and invasion in HuH7 and HepG2 cells. Subsequently, we observed consistent protumorigenic effects of CTH not only in vitro but also in subcutaneous and orthotopic mouse models. Here, our findings suggest that CTH\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    S sulfhydrates Rab7a, which may be associated with HCC progression. We further showed that CTH modulates the expression of autophagy\u2010related proteins in liver tumor cells. In nude mouse subcutaneous xenograft experiments, compared with the vehicle group, the combination of DL\u2010propargylglycine (PPG, CTH inhibitor) and GPC3 CAR\u2010T exhibited better antitumor efficacy compared to PPG or CAR\u2010T alone. Our findings suggest that CTH modulation was associated with altered Rab7a sulfhydration and autophagy and that combined PPG and GPC3 CAR\u2010T therapy exerts better antitumor efficacy.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/3351382","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:11:51Z","timestamp":1792138311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CTH Promotes Liver Cancer Progression and Exploratory Evaluation Supports Enhanced Antitumor Activity of PPG Plus GPC3 CAR\u2010T Cells"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-6169","authenticated-orcid":false,"given":"Yuxin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100005 China  cacms.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1317-8361","authenticated-orcid":false,"given":"Man","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100005 China  cacms.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3078-3451","authenticated-orcid":false,"given":"Xilin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100005 China  cacms.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2634-379X","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The Affiliated Hospital of Qingdao University  Qingdao 266003 Shandong China  qdu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-5895","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100005 China  cacms.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-2359","authenticated-orcid":false,"given":"Xiaopan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100005 China  cacms.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0064"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31247"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1740"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf002"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029648"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0142-8"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00323-z"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0488-6"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01128-9"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.04.020"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65218-9"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02231-w"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30621"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.05.053"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61582-8"},{"key":"e_1_2_12_17_2","unstructured":"SongJ. 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