{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:10:29Z","timestamp":1778850629530,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":134,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Obesity is recognized as a chronic low\u2010grade inflammation that contributes to metabolic disorders. Weight loss (WL) is well known to improve metabolic disorders. However, recent studies have shown that the changes in immune cells associated with obesity exhibit immunological memory even after WL. Obesity impairs skin barrier function and exacerbates inflammatory skin diseases, such as psoriasis. While skin immune cells maintain homeostasis and defense, the impact of obesity on these cells in intact skin is understudied, as research mainly focuses on skin with an inflammatory skin disease model in the context of obesity. The effect of WL on skin immunity is even less clear. Therefore, this study aimed to investigate these discrepancies. Mice were assigned to the lean group (regular diet), the obese group (high\u2010fat diet for 18\u2009weeks), and the WL group (high\u2010fat diet for 9\u2009weeks followed by regular diet for 9\u2009weeks). Following 18\u2009weeks of feeding, mouse skin was excised, and immune cell populations within the skin were analyzed using real\u2010time PCR and flow cytometry. In addition, the effects of WL on psoriasis were examined using an imiquimod\u2010induced psoriasis mouse model. We observed increased expression of ROR\u03b3t, IL\u201017A, and CCL20 in intact skin in both the obese and WL groups. In the psoriasis model, disease severity was further exacerbated by WL. Moreover, whereas the V\u03b34\n                    <jats:sup>+<\/jats:sup>\n                    V\u03b35\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u03b3\u03b4 T cell population was increased in the lean group, the V\u03b34\n                    <jats:sup>\u2212<\/jats:sup>\n                    V\u03b35\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u03b3\u03b4 T cell population remained elevated following WL, similar to levels observed in the obese group. These observations indicated that obesity may imprint a memorized immune response in the skin, which is not abrogated by WL. This study is the first to demonstrate this persistent effect on skin immunity. These findings imply that individuals who have experienced obesity may remain at increased risk for inflammatory skin conditions, even after WL.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/3930910","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:40:01Z","timestamp":1778848801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Fat Diet\u2010Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3968-4733","authenticated-orcid":false,"given":"Wakana","family":"Kamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-6432","authenticated-orcid":false,"given":"Hiromasa","family":"Tanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9804-3378","authenticated-orcid":false,"given":"Rena","family":"Takayashiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6077-1284","authenticated-orcid":false,"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-9550","authenticated-orcid":false,"given":"Shinyo","family":"Ishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-5024","authenticated-orcid":false,"given":"Miki","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-6285","authenticated-orcid":false,"given":"Ko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-9701","authenticated-orcid":false,"given":"Tetsuji","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-122X","authenticated-orcid":false,"given":"Emi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00379.2020"},{"key":"e_1_2_12_2_2","first-page":"1","article-title":"Attempts to Lose Weight Among Adults in the United States, 2013\u20132016","volume":"313","author":"Martin C. 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