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This study aimed to evaluate the therapeutic potential of induced regulatory T cells (iTregs) as an early intervention to mitigate ALI using a polyinosinic\u2010polycytidylic acid (poly I:C)\u2010induced murine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6 mice were intratracheally administered the synthetic double\u2010stranded RNA (dsRNA) analog poly I:C to induce a hyperinflammatory response, followed by intravenous injection of iTreg 1\u2009h later to target the early phase of injury progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of bronchoalveolar lavage fluid (BALF) from poly I:C\u2010treated mice revealed significantly elevated proinflammatory cytokines (interleukin [IL])\u20106, IL\u201012, TNF\u2010\u03b1, interferon [IFN]\u2010\u03b2, and IP\u201010), decreased anti\u2010inflammatory cytokines (IL\u201010 and transforming growth factor [TGF\u2010\u03b2]), increased infiltration of neutrophils, monocytes, and lymphocytes, and evident alveolar damage with thickened walls and edema. Early iTreg administration effectively reversed these effects by suppressing proinflammatory cytokines, restoring IL\u201010 levels, reducing immune cell infiltration, and mitigating tissue damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that iTreg therapy effectively modulates the hyperinflammatory response in ALI and may represent a promising strategy for treating severe inflammatory lung diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/4010824","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:12:23Z","timestamp":1778825543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Induced Regulatory T Cells Attenuate Poly I:C\u2010Triggered Acute Lung Injury by Modulating Cytokine 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