{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:01Z","timestamp":1787017861619,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H00438"],"award-info":[{"award-number":["23H00438"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K15976"],"award-info":[{"award-number":["23K15976"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10172"],"award-info":[{"award-number":["22K10172"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K22683"],"award-info":[{"award-number":["25K22683"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Sj\u00f6gren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development. However, the mechanisms linking age and disease progression remain poorly understood. Age\u2010associated B cells (ABCs), a subset of B cells that increase with age, have been implicated in autoimmune responses, but their role in SjD pathogenesis has not been fully clarified. In this study, we examined labial salivary glands (LSGs) from 44\u2009SjD patients and 11 non\u2010SjD sicca controls. T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    CD20\n                    <jats:sup>+<\/jats:sup>\n                    ABCs were detected infiltrating the glands in SjD patients, especially in individuals in their 40s\u201360s, but were rare in non\u2010SjD sicca controls. To investigate the underlying mechanisms, we used a SjD mouse model at various ages. ABCs (CD11b\n                    <jats:sup>+<\/jats:sup>\n                    CD95\n                    <jats:sup>+<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    ) began locally accumulating in the SGs from the mature\u2010adult stage, earlier than in age\u2010matched controls, while remaining low in cervical lymph nodes (cLNs). To explore the drivers of ABC expansion, we examined the factors involved in ABC differentiation, focusing on interleukin\u201021 (IL\u201021) and interferon\u2010gamma (IFN\u2010\u03b3). This combination of IL\u201021 and IFN\u2010\u03b3 upregulated T\u2010bet expression on B cells in SjD model mice. In situ hybridization (ISH) and flow cytometric analysis revealed that CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, especially follicular helper T (Tfh)\u2010like cells were a major source of IL\u201021 in the SGs of mature\u2010adult\u2010SjD mice. Additionally, ABCs themselves showed elevated expression of IFN\u2010\u03b3 compared to other immune cells, indicating an autocrine mechanism promoting their expansion. Our findings suggest that ABCs accumulate in the SGs of SjD patients and model mice through IL\u201021 signaling from CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and autocrine IFN\u2010\u03b3 activity. This localized expansion may contribute to autoimmune tissue damage. These results provide new insights into how aging\u2010associated immune changes may drive the development and progression of SjD, offering potential targets for therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/4221251","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:07:01Z","timestamp":1774354021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tissue\u2010Specific Expansion of Age\u2010Associated B Cells via IFN\u2010\u03b3 and IL\u201021 Within Salivary Glands in Sj\u00f6gren Disease"],"prefix":"10.1155","volume":"2026","author":[{"given":"Mari","family":"Nishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-8143","authenticated-orcid":false,"given":"Kunihiro","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruka","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigefumi","family":"Matsuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Tsunematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Aota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-8338","authenticated-orcid":false,"given":"Naozumi","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00605-2"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00932-6"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.995895"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1468469"},{"key":"e_1_2_12_5_2","article-title":"Immune Senescence, Immunosenescence and Aging","volume":"3","author":"Lee K. 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