{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:39:19Z","timestamp":1769942359935,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14DZ2260200"],"award-info":[{"award-number":["14DZ2260200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2271600"],"award-info":[{"award-number":["20DZ2271600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91849123"],"award-info":[{"award-number":["91849123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170695"],"award-info":[{"award-number":["82170695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Acute kidney injury (AKI), characterized by inflammation and oxidative stress, is a life\u2010threatening clinical presentation. We previously demonstrated the role of miR\u2010382 in the progression of chronic kidney disease (CKD). However, the role of miR\u2010382 in AKI is unknown. Genetic depletion of miR\u2010382 exacerbated renal dysfunction, histologic lesions, apoptosis of epithelial cells, and oxidative stress in kidneys in ischemia\u2010reperfusion (I\/R)\u2010 and sepsis\u2010induced AKI. In vitro, downregulation of miR\u2010382 accompanied with activation of phosphorylation of signal transducer and activator of transcription 1 (STAT1) were induced in mouse renal tubular epithelial cells (mTECs) with hypoxia\/reoxygenation (H\/R) and lipopolysaccharide (LPS) treatments. Colocalization of phosphorylated STAT1 (p\u2010STAT1) and\n                    <jats:italic>Lotus tetragonolobus<\/jats:italic>\n                    lectin (LTL) suggested the activation of STAT1 signaling in renal epithelial after I\/R injury (IRI). Overexpression of miR\u2010382 in mTECs abrogated phosphorylation of STAT1, generation of interleukin\u20106 (\n                    <jats:italic>Il-6<\/jats:italic>\n                    ), tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (\n                    <jats:italic>Tnf-\u03b1<\/jats:italic>\n                    ), and\n                    <jats:italic>Il-1\u03b2<\/jats:italic>\n                    as well as reactive oxygen species (ROS) and apoptosis after H\/R\u2010 and LPS treatments. Additionally, loss of miR\u2010382 was found in isolated macrophages from kidney during I\/R\u2010induced AKI. Upregulation of miR\u2010382 in Raw264.7 cells inactivated STAT1 signaling and hindered polarization of M1 macrophages inhibiting\n                    <jats:italic>Il-6<\/jats:italic>\n                    and inducible nitric oxide synthase (\n                    <jats:italic>iNos<\/jats:italic>\n                    ). Inhibition of STAT1 pharmacologically reduced\n                    <jats:italic>Il-1\u03b2<\/jats:italic>\n                    ,\n                    <jats:italic>Il-6<\/jats:italic>\n                    , and\n                    <jats:italic>Tnf-\u03b1<\/jats:italic>\n                    in Raw264.7 after H\/R. Taken together, these results demonstrated the protective role of miR\u2010382 in I\/R\u2010 and sepsis\u2010induced AKI, suggesting miR\u2010382 as a novel therapeutic strategy for AKI.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/5266272","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:50:18Z","timestamp":1767952218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA\u2010382 Is Involved in Acute Kidney Injury via Regulating STAT1 Signaling"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-0110","authenticated-orcid":false,"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-3405","authenticated-orcid":false,"given":"Zhouping","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-161X","authenticated-orcid":false,"given":"Ping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-4513","authenticated-orcid":false,"given":"Yi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-2868","authenticated-orcid":false,"given":"Xiaoqiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32563-2"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9972704"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0290"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002568"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000079785.13922.F6"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3671"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101110"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-013-3085-y"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013060640"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00002"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.03.012"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2022.09.003"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq718"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02876-1"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.6.C1640"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.72291"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1522246"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000514532"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12883"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01687-8"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.10.023"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00512.2009"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017040391"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1990"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00133.x"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000109672.83594.02"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101113"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365510802150158"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864984"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6444"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku515"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3452"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00173.2011"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00164.2016"},{"key":"e_1_2_11_36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