{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:05:10Z","timestamp":1771049110841,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370791"],"award-info":[{"award-number":["82370791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PWZxk2022-22"],"award-info":[{"award-number":["PWZxk2022-22"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>B7\u2010H4 is an immunosuppressive molecule extensively studied in tumor diseases and is also of interest in some autoimmune diseases. However, the relationship between B7\u2010H4 and autoimmune thyroid diseases (AITDs) has not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the B7\u2010H4 expression in different tissues of patients with different subtypes of AITDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The B7\u2010H4 protein expression in thyroid tissue of the participants was identified through immunohistochemical analyses while concentrations of plasma soluble B7\u2010H4 (sB7\u2010H4) were detected by enzyme\u2010linked immunosorbent assay (ELISA). Additionally, B7\u2010H4 mRNA expression in peripheral blood mononuclear cells (PBMCs) was evaluated via RT\u2010PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The immunohistochemical findings revealed a decrease in levels of B7\u2010H4 protein in thyroid tissue of Graves\u2019 disease (GD) and Hashimoto\u2019s thyroiditis (HT) patients, compared with those of the normal controls. Similarly, a decrease was observed in the level of B7\u2010H4mRNA expression in PBMCs assayed via RT\u2010PCR. However, based on ELISA results, plasma levels of sB7\u2010H4 were increased in both GD and HT patients compared to those in normal controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The abnormal expression of B7\u2010H4 in AITD patients suggests that it may be involved in the onset and progression of the disease. At the same time, the mechanism of action of B7\u2010H4 in AITD and whether it is a potential therapeutic target need to be further studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/5529891","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:19:33Z","timestamp":1771046373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Abnormal Expression of B7\u2010H4 Is Associated With the Pathogenesis of Autoimmune Thyroid 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