{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:47:03Z","timestamp":1784004423260,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":282,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease (IBD). Leonurine is an active component in\n                    <jats:italic>Leonurus japonicus<\/jats:italic>\n                    , involved in several processes such as inflammation, oxidation, and other processes. This study found that symptoms of colitis induced by 3% dextran sulfate sodium (DSS) solution in C57BL\/6 mice were significantly alleviated after administration of leonurine, in terms of reduced body weight, shortened colon length, disease activity index (DAI), and colonic pathological damage. The expression of the tight junction (TJ) protein claudin\u20101 and occludin markedly increased, the levels of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u20101\u03b2 (IL\u20101\u03b2) significantly decreased. Findings from transmission electron microscopy (TEM) and intestinal permeability assessment experiments indicated that leonurine ameliorates the intestinal barrier. Leonurine regulated the pancreatic secretion pathway, significantly reduced the expression levels of\n                    <jats:italic>Cela2a<\/jats:italic>\n                    and\n                    <jats:italic>Cela3b<\/jats:italic>\n                    , and clearly decreased the abundance of Rikenellaceae_RC9_gut_group, UBA1819,\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    , and\n                    <jats:italic>Oscillibacter<\/jats:italic>\n                    . We proposed that leonurine may improve DSS\u2010induced colitis by regulating the pancreatic secretion pathway, modulating the gut microbiota, and improving intestinal barrier, potentially becoming a candidate for the treatment of UC.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/6626309","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:50:46Z","timestamp":1760161846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leonurine Alleviates DSS\u2010Induced Colitis in Mice by Regulating Pancreatic Secretion Pathway and Gut Microbiota"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3435-1701","authenticated-orcid":false,"given":"TingTing","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-1912","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2914-4472","authenticated-orcid":false,"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5546-0120","authenticated-orcid":false,"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-5750","authenticated-orcid":false,"given":"WeiJie","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-9092","authenticated-orcid":false,"given":"GuoZhong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.023"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-052919-120048"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1097489"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1601101130"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15834"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftab045"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.04.011"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.556526"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.041"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2021044"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01821-12"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21277-2"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149532"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155243"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110375"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00280"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.2741\/3413"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.2014772"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90874.2008"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e31804858f2"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa033"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1390-z"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00393.2015"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060811"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00375-w"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287528"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129961"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09944"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.08.002"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0126-x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1148546"},{"key":"e_1_2_10_36_2","article-title":"The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia","volume":"8","author":"Fujio-Vejar S.","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.005"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034233"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-017-9097-0"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph13110346"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087646"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/6626309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jimr\/6626309","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/6626309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:50:02Z","timestamp":1773780602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jimr\/6626309"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/jimr\/6626309"],"URL":"https:\/\/doi.org\/10.1155\/jimr\/6626309","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6626309"}}