{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:39:09Z","timestamp":1788932349105,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602020"],"award-info":[{"award-number":["81602020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Regulatory T cells (Tregs) and CD4\u2010positive T cells are crucial for the immunological control of systemic lupus erythematosus (SLE). As a crucial component of the adenosine metabolism pathway, CD39 influences the development and functionality of several immune system lymphocyte subsets, such as CD4\u2010positive T cells and Tregs. The purpose of this study was to examine the connection between the activity of SLE disease and the numbers of Tregs and CD4\u2010positive T lymphocytes, as well as the expression levels of the CD39 molecule on these cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and eight SLE patients had peripheral blood drawn. The patients were split into two distinct categories: the SLE active group and the SLE low\u2010activity group, depending on the illness activity. Using flow cytometry, the proportions and absolute numbers of CD4\u2010positive T cells and Tregs, as well as the expression of CD39 on these cells, were measured. Their associations with SLE disease activity were examined. Last, CD39 was assessed as a possible biomarker for the activity of SLE illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the SLE low\u2010activity group, the SLE active group\u2019s peripheral blood had a larger percentage and quantity of CD4\u2010positive T cells. In contrast, it was discovered that the SLE active group had fewer Tregs overall, both in terms of percentage and quantity, than the SLE low\u2010activity group. Compared to those in the SLE low\u2010activity group, patients in the SLE active group exhibited noticeably greater levels of CD39 expression in both Tregs and CD4\u2010positive T cells. Additionally, this study showed a favorable correlation between the percentage and absolute quantity of Tregs and the expression level of CD39 on Tregs. On the other hand, there is a negative correlation between the percentage and absolute quantity of CD4\u2010positive T cells and the expression level of CD39 on these cells. Furthermore, CD39 is a possible biomarker that could help in the identification of SLE disease activity, according to receiver operating characteristic (ROC) curve research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to this study, CD4\u2010positive T cells\u2019 surface CD39 molecule serves a similar purpose to Tregs\u2019, namely immunological suppression. Therefore, a subpopulation of T cells with immunosuppressive properties is defined by CD4+CD39+ T lymphocytes, which may be a more accurate marker for differentiating disease activity in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/6676375","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:03:56Z","timestamp":1772971436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CD39 Expression in Peripheral CD4+ T Lymphocytes Is Associated With Disease Activity in Patients With Systemic Lupus Erythematosus"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4878-118X","authenticated-orcid":false,"given":"Hao","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-5946","authenticated-orcid":false,"given":"Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.05.004"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac610"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead097"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250109"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.4"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.01.002"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047423"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3877"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400931"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00218-7"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2014.922214"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.03.005"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385526-8.00010-2"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/170959"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-358"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13123"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.30"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.70065"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1374938"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead029"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307085124"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20623"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20572"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000566"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2011.06.010"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0018"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.22034\/iji.2023.97037.2527"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac316"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1089-8"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310393262"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1836-8"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417614"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.22541\/au.172958141.17670199\/v1"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/6676375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jimr\/6676375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jimr\/6676375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:03:57Z","timestamp":1772971437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jimr\/6676375"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jimr\/6676375"],"URL":"https:\/\/doi.org\/10.1155\/jimr\/6676375","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6676375"}}