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Immune tolerance is a major factor contributing to viral persistence and viral clearance failure. HBsAg exerts regulatory effects on innate defenses and adaptive responses, limiting the activity of dendritic cells (DCs), natural killer (NK) cells, monocytes\/macrophages, T lymphocytes, and B cells. Furthermore, it fosters a tolerogenic environment via interconnected regulatory cell networks, immune checkpoint molecules, and anti\u2010inflammatory cytokines. HBsAg can enhance the intrahepatic immune\u2013tolerant (IT) microenvironment by downregulating costimulatory molecules and promoting the secretion of immunosuppressive cytokines by intrahepatic nonparenchymal cells. This review systematically summarizes how HBsAg interferes with immune cell function and signaling pathways to establish a tolerogenic environment. We also cover recent progress in treatments that target HBsAg\u2010induced immune tolerance. 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