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In the early stage of systemic lupus erythematosus (SLE), m6A modification can affect the production of autoantibodies by regulating the differentiation of T follicular helper (Tfh) cells and the generation of autoreactive B cells. With the development of SLE, its subsequent action in immune complexes (ICs)\u2010deposited tissues is the promotion of excessive fibrosis, causing progressive organ damage. TGF\u2010\u03b2 is the central driver activating fibroblasts, inducing epithelial\u2010to\u2010mesenchymal transition (EMT), and promoting extensive extracellular matrix (ECM) deposition via the SMAD pathway, ultimately leading to tissue fibrosis and organ damage. m6A regulators can act on both upstream and downstream components of the TGF\u2010\u03b2 signaling pathway. They can synergize with TGF\u2010\u03b2 transcription factors to control the amplification of TGF\u2010\u03b2 signaling. Furthermore, they can work with target molecules downstream of the TGF\u2010\u03b2 receptor (TGF\u2010\u03b2R) to tune TGF\u2010\u03b2\/SMAD pathway activity, increasing the expression of profibrotic transcripts. It is suggested that inhibition of m6A modification targeting the TGF\u2010\u03b2 signaling pathway can effectively reduce EMT and fibrosis in multiple organs, especially in the kidney, improving the long\u2010term prognosis of SLE patients. In this review, we focus on the role of TGF\u2010\u03b2 in the pathogenesis of SLE, the mechanism by which m6A modifications affect the TGF\u2010\u03b2 signaling pathway, and its impact on EMT and fibrosis in different organs, trying to provide a new treatment strategy for the control of SLE symptoms.<\/jats:p>","DOI":"10.1155\/jimr\/7142984","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:40:48Z","timestamp":1790685648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of m6A Modification in the Development of Systemic Lupus Erythematosus via the TGF\u2010\u03b2 Signaling Pathway"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-6466","authenticated-orcid":false,"given":"Xin","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-9945","authenticated-orcid":false,"given":"Rui","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223035"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex260"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa381"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.09.007"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12730"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.3"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3974"},{"key":"e_1_2_13_10_2","doi-asserted-by":"crossref","first-page":"I2006","DOI":"10.1093\/ndt\/gfae069.1242","article-title":"Aberrant m6A Modification Pattern and m6A-Related Proteins Expression in SLE","volume":"39","author":"Tang C.","year":"2024","journal-title":"Nephrology Dialysis Transplantation"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.752736"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2022.01.006"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01464-w"},{"key":"e_1_2_13_14_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ard.2025.06.361","article-title":"POS1006 m6A RNA Methylation Promotes TGF-b Signaling in Systemic Sclerosis","volume":"84","author":"Vlachogiannis N. 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