{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:24:23Z","timestamp":1793157863761,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":112,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011950"],"award-info":[{"award-number":["2023A1515011950"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical College","doi-asserted-by":"publisher","award":["GCC2023019"],"award-info":[{"award-number":["GCC2023019"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    In recent years, a growing body of evidence has suggested a correlation between Hashimoto\u2019s thyroiditis (HT) and the onset and progression of papillary thyroid carcinoma (PTC). However, the mechanism underlying the relationship between HT and PTC remains incompletely understood. This review discusses the literature on the correlation between PTC and HT and summarizes the research concerning the immunological interplay between these two conditions. It also delves into tumor\u2010associated cells (such as CD8+ T cells), tumor\u2010associated macrophages (TAMs), regulatory T cells (Tregs), and cancer\u2010associated fibroblasts (CAFs), alongside other tumor\u2010associated factors, including interleukins (ILs), interferon\u2010gamma (IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    ), tumor necrosis factor\u2010alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), cyclooxygenase\u20102 (COX\u20102), inducible nitric oxide synthase (iNOS), and hypoxia\u2010inducible factor\u20101 (HIF\u20101), highlighting their roles in the interaction between PTC and HT. We also explore the strategic direction of immunotherapy in thyroid malignancies, particularly PTC with HT, and propose novel targeted immunotherapies for advanced thyroid cancer.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/7192808","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:22:18Z","timestamp":1745396538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research Progress on the Immunological Correlation Between Papillary Thyroid Carcinoma and Hashimoto\u2019s 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