{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:15:52Z","timestamp":1788185752218,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":242,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Acute graft\u2010versus\u2010host disease (aGvHD) remains a substantial cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo\u2010HCT). Limited studies explore the association between specific major histocompatibility complex (MHC) alleles and aGvHD or transplant\u2010related mortality (TRM). After a noted clinical trend of higher TRM among a series of patients with aGvHD and MHC class I HLA\u201001:01, we retrospectively evaluated transplant outcomes of 404 adult allo\u2010HCT patients who underwent unmodified allografts between 03\/2010 and 02\/2017. HLA\u201001:01 was expressed by 104 (25.7%) patients. In a univariate analysis, patients who underwent unmodified transplants and expressed HLA\u201001:01 had a higher risk of TRM (HR 1.63 [95% CI: 1.05\u20132.53],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.035). In a multivariate cause\u2010specific Cox model, HLA\u201001:01 was significantly associated with TRM after adjusting for grade II\u2013IV aGvHD, conditioning regimen intensity, and age at transplant (HR 1.59 (95% CI: 1.02\u20132.48)\n                    <jats:italic>p<\/jats:italic>\n                    = 0.039). There were no significant differences in overall survival (OS), aGvHD, or chronic GvHD based on HLA\u201001:01 expression. With confirmation in a larger cohort, these findings have potential implications for the selection of allograft type, conditioning regimen, and post\u2010transplant monitoring for this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/7237488","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:37:31Z","timestamp":1788183451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA\u2010A\n                    <i>\u2009<\/i>\n                    <sup>\u2217<\/sup>\n                    01:01 Allele Is Associated With Increased Risk of Transplant\u2010Related Mortality After MHC Matched Unmodified Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-3542","authenticated-orcid":false,"given":"Emily A.","family":"Cowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-974X","authenticated-orcid":false,"given":"Samantha","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4094-1346","authenticated-orcid":false,"given":"Rachel E.","family":"Reingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-0245","authenticated-orcid":false,"given":"Sarah","family":"Samorodnitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-720X","authenticated-orcid":false,"given":"Sean M.","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-6559","authenticated-orcid":false,"given":"James W.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira A.","family":"Fatmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-3416","authenticated-orcid":false,"given":"Molly","family":"Maloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-5053","authenticated-orcid":false,"given":"Sergio","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-5766","authenticated-orcid":false,"given":"Doris M.","family":"Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann A.","family":"Jakubowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-3199","authenticated-orcid":false,"given":"Alina","family":"Markova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"2062","article-title":"Phase 3 Study Comparing Methotrexate and Tacrolimus With Methotrexate and Cyclosporine for Prophylaxis of Acute Graft-Versus-Host Disease After Marrow Transplantation From Unrelated Donors","volume":"96","author":"Nash R. 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