{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:28:56Z","timestamp":1786606136529,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":223,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160309"],"award-info":[{"award-number":["82160309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia","doi-asserted-by":"publisher","award":["2025QN08069"],"award-info":[{"award-number":["2025QN08069"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia","doi-asserted-by":"publisher","award":["2025LHMS08006"],"award-info":[{"award-number":["2025LHMS08006"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by dynamically recurring inflammatory episodes, and targeting T cells has been shown to effectively alleviate RA. Caveolin\u20101 (CAV\u20101) is widely distributed in the membrane structures of immune cells and participates in the differentiation and homeostasis of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell subsets through signal transduction; however, its role in RA has not yet been investigated. This study aimed to examine the expression pattern and clinical relevance of CAV\u20101 in RA, and to elucidate its regulatory role in CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell\u2010mediated immune imbalance during disease progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective clinical study was conducted to detect serum CAV\u20101 levels in RA and healthy controls (HCs), characterize its expression in peripheral blood CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells and synovial tissues, and evaluate its association with clinical parameters. A collagen\u2010induced arthritis (CIA) mouse model was established and treated with the CAV\u20101 inhibitor hydroxypropyl\u2010\u03b2\u2010cyclodextrin (HP\u2010\u03b2\u2010CD). Joint pathology, CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell infiltration, differentiation, and the expression of related inflammatory cytokines were assessed using histopathological and immunological approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAV\u20101 expression in serum, CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells, and synovial tissues was significantly higher in RA than in HC and was positively correlated with anti\u2010cyclic citrullinated peptide antibody (Anti\u2010CCP) and rheumatoid factor (RF) levels. HP\u2010\u03b2\u2010CD treatment markedly relieved joint inflammation and structural damage in CIA mice, reduced CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell infiltration, and significantly suppressed the differentiation of T helper 1, T helper 17, and regulatory T (Treg) cells, accompanied by decreased expression of IFN\u2010\u03b3, IL\u201017A, and transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      CAV\u20101 is aberrantly upregulated in RA and contributes to disease pathogenesis by regulating CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell differentiation. Targeting CAV\u20101 may represent a promising strategy for RA diagnosis and immunomodulatory therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/7245795","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:49:21Z","timestamp":1786603761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cyclodextrin Inhibits Caveolin\u20101 to Regulate CD4\n                    <sup>+<\/sup>\n                    T Cell Subset Differentiation and Ameliorate Rheumatoid Arthritis Progression"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9883-266X","authenticated-orcid":false,"given":"Yajie","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1880-3875","authenticated-orcid":false,"given":"Peiyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6657-2155","authenticated-orcid":false,"given":"Yinping","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-8915","authenticated-orcid":false,"given":"Yongfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3933-0345","authenticated-orcid":false,"given":"Lingyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.121506.124841"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30501.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology12111402"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05134-8"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-252320"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3734-15.2016"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55819-y"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36767-5"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S398780"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42089"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.062"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-025-01180-1"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.49"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38107"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106255"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001063"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-672428"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00827-y"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.035"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01534.x"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.03.007"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.150456"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200968"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/75611"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01321-7"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7151"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2020.02.008"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100161"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01190-w"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53264-8"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01036-7"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C110.155820"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06878"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5419"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.08.002"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.12.002"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108290"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701572200"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.016"},{"key":"e_1_2_11_41_2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbamcr.2011.01.028","article-title":"The 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