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Factors such as activation, differentiation, and cell metabolism have been proposed to determine the relative susceptibility of cells to HIV\u20101 infection. HIV\u20101 reservoirs are seeded early during the acute phase of infection, but the cell composition of these reservoirs evolves in the transition to chronic infection. This suggests that there are factors during the acute phase that may alter the intrinsic susceptibility of CD4+ T\u2010cells to HIV\u20101. We investigated here the influence of common cytokines known to be secreted during the acute phase and to play a role in either T cell homeostasis or HIV\u20101 infection on activation, differentiation, metabolic activity, and HIV\u20101 susceptibility of CD4+ T\u2010cells. We show that the proinflammatory cytokines interleukin (IL)\u20102, IL\u20107, and IL\u201015 induce cellular activation, differentiation to effector profile, increase in metabolic capacity, and HIV\u20101 susceptibility. In contrast, IL\u201021, another cytokine from the gamma\u2010chain (\u03b3c) family, showed opposing effects on the same parameters, including decreasing oxidative phosphorylation (OXPHOS) and HIV\u20101 infection. We also show that IL\u201010 and interferon (IFN)\u2010\u03b1 are able to at least partially revert the cellular and metabolic changes induced by IL\u20102 or IL\u20107 and reduce the cells\u2019 susceptibility to HIV\u20101.<\/jats:p>","DOI":"10.1155\/jimr\/7633359","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:37:06Z","timestamp":1788413826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Effect of Cytokines on CD4+ T\u2010Cell Activation, Metabolism, and Susceptibility to HIV\u20101 Infection"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-3123","authenticated-orcid":false,"given":"Amal","family":"Elfidha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-3735","authenticated-orcid":false,"given":"Erick","family":"De la Torre 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