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Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease\u2010modulating effects and potential adverse side effects. Purinergic P2 receptors (P2Rs; P2X and P2Y subtypes) have emerged as key modulators of allergic inflammation and regulate mast cell degranulation, T helper 2 (Th2) cytokine release, eosinophil recruitment, and NLRP3 inflammasome activation. Natural products, including polyphenols, flavonoids, terpenoids, and alkaloids, demonstrate multitarget anti\u2010inflammatory effects and have the potential to modulate P2R signaling. However, direct evidence of their activity on P2Rs in AR remains limited. 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