{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:02:23Z","timestamp":1779667343616,"version":"3.53.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":128,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric allergic diseases vary by region. Subtropical sensitization profiles and their clinical implications remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this retrospective study, specific immunoglobulin E (sIgE) levels to eight common allergens were obtained from children assessed for allergy\u2010associated symptoms in our department between November 1, 2017, and April 29, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Of the 1755 patients,\n                      <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>\n                      (Der p) (46.5%) and\n                      <jats:italic>Dermatophagoides farinae<\/jats:italic>\n                      (Der f; 45.7%) showed high rates of sensitization. More than 80% of shrimp\u2010sensitized children exhibited cross\u2010reactivity to Der p, Der f, and cockroach. After adjusting for potential confounding variables, inhalant sensitization (OR\u2009=\u20092.131; 95% confidence interval [CI]: 1.506\u20133.015;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001) and polysensitization (OR\u2009=\u20091.480; 95% CI: 1.023\u20132.141;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038) were both associated with an increased risk of allergic airway disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study identified the \u201cmite\u2013shrimp\u201d sensitization cluster in subtropical children and establishes inhalant sensitization and polysensitization as the key risk factor in allergic respiratory diseases. These findings support the development of region\u2010specific and component\u2010resolved diagnostic strategies for pediatric allergy prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/8815583","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T23:03:41Z","timestamp":1778367821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sensitization of Common Allergens and Cosensitization Patterns Among Children in Guangzhou, China"],"prefix":"10.1155","volume":"2026","author":[{"given":"Xiaoyin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaona","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-6549","authenticated-orcid":false,"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-0358","authenticated-orcid":false,"given":"Weiping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-0357","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12819"},{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/tcrm.1.2.115.62907","article-title":"Risk Factors of Allergic Rhinitis: Genetic or Environmental?","volume":"1","author":"Wang D. 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