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Recently, we have demonstrated that the expression of VEGF\u2010A in human classical monocytes is positively associated with the number of swollen and painful joints in SpA patients. Therefore, we tested whether the anti\u2010VEGF\u2010A therapy can affect the hallmarks of SpA in the SKG mouse model. When initiated at the disease onset, the administration of anti\u2010VEGF\u2010A monoclonal antibodies (mAbs) significantly reduced the objective symptoms of SpA in the curdlan suspension\u2010treated mice compared to their untreated and isotypic control\u2010treated counterparts. Micro\u2010computed tomography (CT) imaging revealed substantial benefits of the treatment, with anti\u2010VEGF\u2010A mAbs\u2010treated mice exhibiting preserved joint spaces, reduced number and depth of bone erosions, and limited new bone formation in hind paws, calcaneus, sacroiliac joints, and caudal vertebrae. These effects remained in contrast to the pronounced damage and osteogenesis in relevant skeletal regions of control animals. The histological assessment confirmed reduced synovial inflammation and bone erosions in anti\u2010VEGF\u2010A mAbs\u2010treated mice, underscoring the efficacy of the treatment in mitigating SpA bone damage. Collectively, anti\u2010VEGF\u2010A mAbs treatment favors the maintenance of joint and spine structures, alleviates bone destruction and osteogenesis, and reduces local inflammation in the mouse SpA model. Our study pinpoints anti\u2010VEGF\u2010A mAb therapy as a promising avenue to understand the SpA pathogenesis and as a treatment option. It also addresses vascular and inflammatory aspects of the disease and illustrates the potential of the SKG mouse SpA model for assessing the long\u2010term safety of anti\u2010VEGF\u2010A therapy before its clinical translation.<\/jats:p>","DOI":"10.1155\/jimr\/8870895","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:41:42Z","timestamp":1748587302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Monoclonal Antibodies Against Vascular Endothelial Growth Factor A (VEGF\u2010A) Reduce Synovitis, Bone Damage, and Osteogenesis in an SKG Mouse Model of 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