{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:25:25Z","timestamp":1789295125792,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":132,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mounting evidence shows that lipid metabolism and ferroptosis contribute to ulcerative colitis (UC), but the mechanism remains unclear. This study aimed to identify related biomarkers, clarify their roles in UC, and provide insights into optimized therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>UC transcriptome, lipid metabolism, and ferroptosis\u2010related gene (FRG) data were analyzed. Biomarkers were screened via differential expression analysis, consensus clustering, Venn, and machine learning, with expression validation. Receiver operating curve (ROC) analysis assessed predictive efficacy; functional enrichment, molecular regulatory, and immune infiltration analyses were performed. Real\u2010time PCR verified candidate biomarkers in clinical samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two biomarkers (acyl\u2010CoA synthetase ligases 4 [\n                      <jats:italic>ACSL4<\/jats:italic>\n                      ] and prostaglandin\u2010endoperoxide synthase 2 [\n                      <jats:italic>PTGS2<\/jats:italic>\n                      ]) were identified that distinguished UC from control samples. They may involve hematopoietic cell lines, cytokine\u2013cytokine receptor interaction, and MALAT1 binding hsa\u2010miR\u2010576\u20105p\/hsa\u2010miR\u2010503\u20105p. Notably, 27 differentially infiltrated immune cells were found (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.05), with CD56dim natural killer cells negatively correlating with\n                      <jats:italic>ACSL4<\/jats:italic>\n                      \/\n                      <jats:italic>PTGS2<\/jats:italic>\n                      . Both genes were significantly upregulated in the UC clinical samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ACSL4<\/jats:italic>\n                      and\n                      <jats:italic>PTGS2<\/jats:italic>\n                      are lipid metabolism\u2010 and ferroptosis\u2010related biomarkers of UC, laying a foundation for clinical treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jimr\/9283449","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:47:37Z","timestamp":1778665657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification and Analysis of Biomarkers Associated With Lipid Metabolism and Ferroptosis in Ulcerative 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