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In this study, we investigated the immune response of IBV using reconstituted samples of the commercial H120 Mass\u2010I vaccine (Zoetis) against SARS\u2010CoV\u20102 infection. Bioinformatics analyses, serological assays, and neutralization tests were conducted to evaluate the neutralizing capacity of anti\u2010IBV antibodies against SARS\u2010CoV\u20102 in serum samples from poultry farm workers exposed to the IBV\u2010H120 vaccine. Mouse immunization assays and flow cytometry analysis were conducted to characterize the immune response triggered by IBV\u2010H120. Finally, a histological analysis of the lungs of Syrian hamsters vaccinated with IBV and challenged with SARS\u2010CoV\u20102 (Wuhan and Delta strains) was conducted to evaluate the protective potential of the vaccine. Neutralizing antibodies against IBV\u2010H120 were detected in the serum of poultry farm workers, indicating cross\u2010reactivity with SARS\u2010CoV\u20102. The immune response in mice immunized with IBV\u2010H120 demonstrated that only the intranasal and oral routes were effective against SARS\u2010CoV\u20102. An increase in the percentage of CD19\n                    <jats:sup>+<\/jats:sup>\n                    induced by IBV\u2010H120 vaccination was demonstrated by flow cytometry. Intranasal administration of the IBV\u2010H120 vaccine reduced lung damage in Syrian hamsters against the Wuhan and Delta variants of SARS\u2010CoV\u20102. IBV\u2010H120 elicited both humoral and cellular immune responses in mice and reduced lung damage in hamsters challenged with the Wuhan and Delta variants. This indicates that it could be an improved vaccine for controlling SARS\u2010CoV\u20102.\n                  <\/jats:p>","DOI":"10.1155\/jimr\/9309800","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:29:43Z","timestamp":1774852183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuated Infectious Bronchitis Virus (IBV) Vaccination Induces Protective Humoral and Cellular Immunity Against SARS\u2010CoV\u20102 in Mammals"],"prefix":"10.1155","volume":"2026","author":[{"given":"Ney","family":"de Carvalho Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio Fraga","family":"van Tilburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Bezerra","family":"da 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