{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:38Z","timestamp":1790776898674,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":272,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/F007450\/1"],"award-info":[{"award-number":["BB\/F007450\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Maternal nutrition during offspring development influences the offspring physiology and risk of long\u2010term chronic disease. Here, we investigate the effects of maternal high\u2010fat diet during distinct developmental windows (preimplantation alone, EmbHFD; or throughout gestation and lactation, HFD) on adult offspring metabolic, molecular and motor behavioural outcome. Our mouse model, utilising healthy nonobese MF1 mothers, induced distinct offspring outcomes dependent upon dietary duration with some sex\u2010specific effects. EmbHFD offspring had high serum leptin (females), elevated systolic blood pressure (SBP), low locomotory activity and diminished motor coordination. Similarly, HFD offspring not only had raised serum leptin, high SBP and poor motor coordination but also experienced excess weight gain, deficits in energy metabolism, reduced relative brown adipose tissue (BAT) mass (females) and increased muscle lipid accumulation. Transcriptomic profiling of HFD female offspring revealed upregulation of thermogenic and lipid\u2010handling genes (e.g.,\n                    <jats:italic>Ucp1<\/jats:italic>\n                    and\n                    <jats:italic>ApoE<\/jats:italic>\n                    ) in BAT alongside downregulation of mitotic regulators, suggesting impaired regenerative capacity. Collectively, these findings demonstrate, first, the risk to offspring of even transient maternal fatty diet without maternal obesity. Second, they highlight the sensitivity of periconceptional nutrition on the emergence of offspring multisystem metabolism and physiology, supporting the Developmental Origins of Health and Disease (DOHaD) concept.\n                  <\/jats:p>","DOI":"10.1155\/jnme\/5286440","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:12Z","timestamp":1790775552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal High\u2010Fat Diet, During Preimplantation or Gestation\/Lactation, Alters Mouse Offspring Metabolic, Molecular and Locomotor Phenotypes"],"prefix":"10.1155","volume":"2026","author":[{"given":"Irene","family":"Peral-Sanchez","sequence":"first","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-1666","authenticated-orcid":false,"given":"Eda","family":"Sezer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"},{"name":"Medical Sciences Faculty of Medicine University of Bak\u0131r\u00e7ay  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-8200","authenticated-orcid":false,"given":"Diego A.","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"},{"name":"Department of Ophthalmology Bascom Palmer Eye Institute University of Miami Miller School of Medicine  Miami Florida USA  miami.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-710X","authenticated-orcid":false,"given":"Philip C.","family":"Calder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-919X","authenticated-orcid":false,"given":"Patrick C.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Centre for Biomarker Research Department of Pharmacy School of Applied Sciences University of Huddersfield  Huddersfield HD1 3DH UK  hud.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Morris","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Southampton Southampton General Hospital  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette L.","family":"Norman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Ward","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom P.","family":"Fleming","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Southampton Southampton General Hospital  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith J.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Smyth","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Southampton Southampton General Hospital  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-6419","authenticated-orcid":false,"given":"Sandrine","family":"Willaime-Morawek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Southampton General Hospital University of Southampton  Southampton SO16 6YD UK  southampton.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309322"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.8471"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05047-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.940937"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30107-3"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.909762"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-024-01994-6"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12817"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101477"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174421000672"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202100470"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30312-X"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2023.107321"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes13010031"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.04.020"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174426100518"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad093"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03574-w"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3791\/2610"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2015.39"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.3791\/2609"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.12.018"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.3791\/51445"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3791\/52793"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S246754"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r19"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800205"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0400527"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.008"},{"key":"e_1_2_11_33_2","volume-title":"The Effect of High-Fat Diet During Mouse Preimplantation and Pregnancy-Lactation on Uterine Fluid Protein Composition, Maternal Metabolism and Offspring Health","author":"Peral Sanchez I.","year":"2023"},{"key":"e_1_2_11_34_2","volume-title":"The Impact of Maternal High Fat Diet on Offspring Brain, Behaviour and Cognitive Functions","author":"Sezer E.","year":"2024"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa183"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30311-8"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.3148\/cjdpr-2023-019"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0957"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-022-09512-y"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqad182"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309184"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-025-01830-2"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305472"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115935"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-01060-5"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34345"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77362-x"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2668-9"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu17091464"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080350204"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq042"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-025-01459-x"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2721-y"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07473-5"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79604-4"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158179"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011376"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095004"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.042"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.6.6774"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.011"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.662"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci37048"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2583"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1808"}],"container-title":["Journal of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jnme\/5286440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jnme\/5286440","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jnme\/5286440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:15Z","timestamp":1790775555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jnme\/5286440"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jnme\/5286440"],"URL":"https:\/\/doi.org\/10.1155\/jnme\/5286440","archive":["Portico"],"relation":{},"ISSN":["2090-0724","2090-0732"],"issn-type":[{"value":"2090-0724","type":"print"},{"value":"2090-0732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5286440"}}