{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T16:00:44Z","timestamp":1780156844466,"version":"3.54.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":149,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["11201"],"award-info":[{"award-number":["11201"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Alzheimer\u2019s disease (AD), a major neurodegenerative disorder, is characterized by progressive cognitive decline and the accumulation of amyloid\u2010beta and tau proteins in the brain. Intermittent fasting (IF) is being explored as a dietary intervention to mitigate AD\u2010related effects, possibly by modulating factors such as reelin and\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein, which are involved in synaptic function and AD pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included six groups of rats: Ctrl, Ctrl.ADF, Ctrl.TRF, AD, AD.TRF, and AD.ADF. AD was induced by bilateral ICV injections of 5\u2009\u03bcL\u2009A\u03b2. To prove fasting, blood glucose levels were assessed with a glucometer. Memory and learning were assessed using the Morris Water Maze (MWM) test, and hippocampal reelin and\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein concentrations were quantified via ELISA. Electrophysiological recordings were analyzed using eProbe software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TRF was more effective than ADF in improving cognitive function in AD rats, as indicated by a significant increase in TSGQ [\n                      <jats:italic>F<\/jats:italic>\n                      (5,40)\u2009=\u20095.590,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01] and swimming speed [\n                      <jats:italic>F<\/jats:italic>\n                      (3,21)\u2009=\u2009114.3,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01], along with a significant reduction in latency time and path length (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Both TRF and ADF significantly increased reelin concentration and neuronal firing rate (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), whereas only TRF led to a significant decrease in\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that TRF may enhance spatial memory and reduce\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein accumulation in AD rats, possibly through mechanisms associated with synaptic plasticity and neuroprotection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jnme\/7185647","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:01:26Z","timestamp":1780153286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010Restricted Feeding Preserves Synaptic Function and Modulates Reelin and\n                    <i>\u03b1<\/i>\n                    \u2010Synuclein in an Acute Amyloid\u2010\n                    <i>\u03b2<\/i>\n                    Rat Model: A Comparative Study With Alternate\u2010Day Fasting"],"prefix":"10.1155","volume":"2026","author":[{"given":"Zeynab","family":"Maleki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-6440","authenticated-orcid":false,"given":"Mohammad Ali","family":"Mirshekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Montazerifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Etminani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Keykha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.32394\/rpzh.2021.0154"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32205-4"},{"key":"e_1_2_9_3_2","unstructured":"(Who) Who Dementia 2023 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00391-7"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666190503152555"},{"key":"e_1_2_9_6_2","unstructured":"What is Alzheimer\u2032s Disease? 2014 ted.com\/talks\/ivan_seah_yu_jun_what_is_alzheimer_s_disease."},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102339"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255555"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4269"},{"key":"e_1_2_9_10_2","article-title":"Hippocampal Reduction of \u03b1-Synuclein via RNA Interference Improves Neuropathology in Alzheimer\u2032s disease Mice","author":"Leit\u00e3o A. 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