{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T14:01:34Z","timestamp":1780236094558,"version":"3.54.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":150,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Xerophthalmia during pregnancy is a major public health problem, associated with an increased risk of morbidity and mortality among pregnant women. Studies indicated that Ethiopia is a country with the highest rates of xerophthalmia. However, most studies emphasize biochemical deficiency or night blindness rather than the full clinical spectrum. This study was intended to assess all clinical forms of xerophthalmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study assessed the prevalence and associated factors of xerophthalmia among pregnant women attending antenatal care in general and referral public hospitals of the Tigray Region, Ethiopia, in 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using an institution\u2010based cross\u2010sectional design, a total of 1387 pregnant women were selected using a systematic random sampling technique to assess for xerophthalmia. The data collection was conducted from February 2024 to July 2024. Results were presented as adjusted odds ratios (AORs) with 95% CI and significance level\n                      <jats:italic>p<\/jats:italic>\n                      value (&lt; 0.05), which expresses the magnitude of the effect of each category on the outcome relative to the reference category.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the total 1387 selected pregnant women, 1355 participated, yielding a response rate of 97.83%. The prevalence of xerophthalmia was 25% (95% CI: 22.7%\u201327.3%). Factors significantly associated with xerophthalmia include inadequate sanitation (AOR\u2009=\u20092.369; 95% CI: 1.335\u20134.202), not taking iron supplementation (AOR\u2009=\u20092.577; 95% CI: 1.551\u20134.284), fewer antenatal care follow\u2010ups (AOR\u2009=\u20093.462; 95% CI: 2.203\u20135.441), not owning livestock (AOR\u2009=\u20099.528; 95% CI: 5.666\u201316.023), history of miscarriage (AOR\u2009=\u20097.984; 95% CI: 4.361\u201314.614), alcohol consumption during pregnancy (AOR\u2009=\u20098.045; 95% CI: 3.94\u201316.425), consuming inadequate vegetables (AOR\u2009=\u20091.68; 95% CI: 1.18\u20132.40), and mid\u2010upper arm circumference &lt; 23\u2009cm (AOR\u2009=\u20092.20; 95% CI: 1.58\u20133.08).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Xerophthalmia among pregnant women in the Tigray Region indicates a critical public health concern. Inadequate sanitation, alcohol consumption during pregnancy, history of miscarriage, not owning livestock, low ANC attendance, inadequate vegetable consumption, undernutrition, and lack of iron supplementation during pregnancy were significantly associated with xerophthalmia. Therefore, we recommend adequate sanitation, avoiding alcohol consumption during pregnancy, preventing miscarriage, owning livestock in the household, ANC attendance, consuming vegetables, preventing acute malnutrition, and iron supplementation during pregnancy as effective interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jnme\/8469511","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T13:23:47Z","timestamp":1780233827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Xerophthalmia and Associated Factors Among Pregnant Women in Tigray Region, Ethiopia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-7886","authenticated-orcid":false,"given":"Ebud Ayele","family":"Dagnazgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1591-4554","authenticated-orcid":false,"given":"Shewit Engdashet","family":"Berhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-977X","authenticated-orcid":false,"given":"Guesh","family":"Gebreayezgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8503-8611","authenticated-orcid":false,"given":"Goitom","family":"Girmay Gebremariam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9424","authenticated-orcid":false,"given":"Yohannes Kinfe","family":"Gebreyohannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-6974","authenticated-orcid":false,"given":"Tsega Gebremichael","family":"Gebremeskel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1591-1600","authenticated-orcid":false,"given":"Embaba Tekelaye","family":"Welesemayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-1659","authenticated-orcid":false,"given":"Teklehaymanot Huluf","family":"Abraha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9543-7630","authenticated-orcid":false,"given":"Gebregziabher Kidanemariam","family":"Asfaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_15_1_2","volume-title":"Vitamin A Deficiency and Its Consequences: A Field Guide to Detection and Control","author":"Sommer A.","year":"1995"},{"key":"e_1_2_15_2_2","volume-title":"Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995-2005: WHO Global Database on Vitamin A Deficiency","author":"Organization W. 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