{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:59:04Z","timestamp":1790776744033,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":272,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024597","name":"Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand","doi-asserted-by":"publisher","award":["RGNS 65\u2013124"],"award-info":[{"award-number":["RGNS 65\u2013124"]}],"id":[{"id":"10.13039\/501100024597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Cratoxylum formosum<\/jats:italic>\n                    (CF) is a phenolic\u2010rich plant and exhibits\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidant properties, yet its in vivo therapeutic potential remains uncharacterized. This study evaluated the antidiabetic efficacy of an ethanolic CF leaf extract using high\u2010fat diet\/streptozotocin\u2010induced diabetic mice, complemented by enzymatic and INS\u20101 rat insulinoma cell line assays. This study found that 5\u2010O\u2010caffeoylquinic acid (5\u2010CQA) was identified as the major phenolic compound in the CF leaf extract. In vitro, CF extract inhibited \u03b1\u2010amylase and \u03b1\u2010glucosidase activities and protected INS\u20101\u2009cells from high\u2010glucose\u2010induced cytotoxicity. In diabetic mice, CF extract administration attenuated hyperglycemia, partially preserved serum insulin and C\u2010peptide levels, and suppressed serum neuropeptide Y (NPY) concentrations. Histological analysis confirmed the preservation of pancreatic islet architecture and pancreatic \u03b2\u2010cell mass. These findings indicate that CF extract supports glycemic regulation and pancreatic \u03b2\u2010cell preservation, warranting further exploration as a candidate for diabetes management.\n                  <\/jats:p>","DOI":"10.1155\/jnme\/8893700","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:24:24Z","timestamp":1790774664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Antidiabetic Effects of\n                    <i>Cratoxylum formosum<\/i>\n                    Leaf Extract in Low\u2010Dose Streptozotocin\u2010 and High\u2010Fat Diet\u2010Induced Diabetic Mice"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-8460","authenticated-orcid":false,"given":"Nipaporn","family":"Muangchan","sequence":"first","affiliation":[{"name":"Department of Biopharmacy Faculty of Pharmaceutical Sciences Ubon Ratchathani University  Ubon Ratchathani Thailand  ubu.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-1438","authenticated-orcid":false,"given":"Suwattanee","family":"Kooptiwut","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand  mahidol.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-1302","authenticated-orcid":false,"given":"Anchalee","family":"Vattarakorn","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand  mahidol.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-9123","authenticated-orcid":false,"given":"Bancha","family":"Yingngam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Technology Faculty of Pharmaceutical Sciences Ubon Ratchathani University  Ubon Ratchathani Thailand  ubu.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-7199","authenticated-orcid":false,"given":"Kanchana","family":"Suksri","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Biopharmaceutical Sciences Faculty of Pharmaceutical Sciences Burapha University  Chonburi Thailand  buu.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/ajm.ajm_53_20"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21101374"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.10.024"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.12.035"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox4040662"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-019-00760-8"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2926"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60281-9"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2022.082"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.778"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3555-9"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2025.2460385"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.34172\/jhp.2020.36"},{"key":"e_1_2_13_14_2","first-page":"152","volume-title":"Methods in Enzymology","author":"Singleton V. 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