{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:16:56Z","timestamp":1774621016566,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005068","name":"Jimma University","doi-asserted-by":"publisher","award":["JUIH\/IRB\/583\/2023"],"award-info":[{"award-number":["JUIH\/IRB\/583\/2023"]}],"id":[{"id":"10.13039\/501100005068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Common mental disorders (CMDs) are increasingly recognized as a major public health challenge worldwide, with adolescent girls bearing a disproportionate burden. Moreover, iron deficiency (ID) and iron deficiency anemia (IDA) remain prevalent nutritional problems among adolescents. Observational studies have highlighted that the prevalence of CMD is higher among anemic individuals compared to their non\u2010anemic counterparts. This study hypothesizes that preventing anemia through weekly iron and folic acid supplementation (WIFAS) among adolescent girls may have a positive effect on CMDs. However, the potential effect of WIFAS on CMDs remains unexplored. This critical evidence gap highlights the need for targeted research. Therefore, this study aimed to assess the effect of WIFAS on CMD among adolescent girls in the Central Ethiopia Region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study employed a school\u2010based, parallel\u2010cluster randomized controlled trial (RCT) design, involving 306 adolescent girls across 12 clusters in the Silti and Kibet Districts of the Central Ethiopia Region. Participants were proportionally allocated, with 153 girls assigned to the intervention group (six clusters in Silti District) and 153 to the control group (six clusters in Kibet District). The outcome variable, CMD score, was treated as a continuous measure and assessed using the World Health Organization\u2019s (WHO) Self\u2010Reporting Questionnaire (SRQ\u201020). Data were collected at baseline and endline, with the latter conducted 6\u2009months after the completion of the WIFAS. Linear mixed\u2010effects models (LMEMs) were used to examine the association between WIFAS and CMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The findings of this study indicated that adolescents who received WIFAS had significantly lower CMD scores compared to those who did not (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.12; 95% CI: \u22121.68, \u22120.55). The unadjusted mean difference was \u22120.88 (Model 1:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.88; 95% CI: \u22121.47, \u22120.29). This association remained significant after adjusting for baseline CMD score (Model 2:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.01; 95% CI: \u22121.58, \u22120.45), parental sociodemographic characteristics (Model 3:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.12; 95% CI: \u22121.68, \u22120.55), and in the fully adjusted model (Model 4:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.12; 95% CI: \u22121.68, \u22120.55).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this study revealed that WIFAS significantly reduced CMD scores among adolescent girls. This suggests that WIFAS may offer mental health benefits in addition to its known role in preventing anemia and ID. Hence, integrating WIFAS into school\u2010based health programs should be prioritized as a potential strategy to improve mental health outcomes among adolescent girls.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: PACTR202309541331083\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jnme\/9500345","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:30:31Z","timestamp":1770618631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["School\u2010Based Weekly Iron\u2013Folic Acid Supplementation and Its Effect on Mental Health Outcomes Among Adolescent Girls in Central Ethiopia: A Cluster\u2010Randomized Controlled Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-7610","authenticated-orcid":false,"given":"Shemsu","family":"Kedir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-031X","authenticated-orcid":false,"given":"Dessalegn","family":"Tamiru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-1509","authenticated-orcid":false,"given":"Beyene Wondafrash","family":"Ademe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-5417","authenticated-orcid":false,"given":"Kalkidan Hassen","family":"Abate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232007"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244x-14-194"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)62382-x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"e_1_2_13_5_2","volume-title":"Global Health Data Exchange 2019","author":"IHME","year":"2019"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-025-06932-y"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60512-6"},{"key":"e_1_2_13_8_2","doi-asserted-by":"crossref","unstructured":"BeregoY. 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