{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:14Z","timestamp":1787017874370,"version":"build-2736575974"},"reference-count":94,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":137,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The medicinal properties of\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    L. (turmeric) have long been recognized, especially in traditional medicine, where it has been used to treat diverse ailments for thousands of years. The bioactive polyphenol responsible for the health benefits associated with\n                    <jats:italic>C. longa<\/jats:italic>\n                    is curcumin, which offers a variety of health advantages, particularly, anti\u2010inflammatory properties. This review discusses the molecular mechanisms underlying the anti\u2010inflammatory properties of curcumin, focusing on its interaction with significant inflammatory signaling pathways, modulation of the gut microbiota, and antioxidant activity. The therapeutic potential of curcumin is rooted in its ability to reduce enzymes such as COX\u20102 and LOX, downregulate proinflammatory cytokines, and block the NF\u2010\u03baB pathway. In addition to its ability to decrease oxidative stress, a primary mediator of inflammation, curcumin also functions in scavenging reactive oxygen species (ROS) and activating antioxidant defense systems. This review further highlights the clinical relevance of curcumin in chronic inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, and cardiovascular disorders. Despite its encouraging therapeutic potential, curcumin bioavailability remains a major problem, prompting advancements in drug administration methods. Further research is needed to improve its formulations, study how curcumin synergizes with other treatments, and conduct clinical studies.\n                  <\/jats:p>","DOI":"10.1155\/jnme\/9985642","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:28:03Z","timestamp":1779103683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Review of Curcumin in Chronic Disease Management: Anti\u2010Inflammatory Pathways, Antioxidant Activity, and Therapeutic Advances"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-9203","authenticated-orcid":false,"given":"Sammra","family":"Maqsood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-5920","authenticated-orcid":false,"given":"Farhang Hameed","family":"Awlqadr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4968-9184","authenticated-orcid":false,"given":"Iffat","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5290-7631","authenticated-orcid":false,"given":"Muhammad Tayyab","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeed","family":"Mukhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2089-9321","authenticated-orcid":false,"given":"Emmanuel","family":"Laryea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"crossref","DOI":"10.1201\/b10787-14","article-title":"Turmeric, the Golden Spice","author":"Prasad S.","year":"2011","journal-title":"Herbal Medicine: Biomolecular and Clinical Aspects"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077195"},{"key":"e_1_2_15_3_2","first-page":"113","article-title":"Historical Significance and Modern Applications of Turmeric (Curcuma longa) in Traditional Medicine and Beyond","volume":"5","author":"Zeeshan A.","year":"2023","journal-title":"International Research Journal of Engineering and Technology"},{"key":"e_1_2_15_4_2","first-page":"15","volume-title":"Aging Research in Iran: Focus on Turmeric and Curcumin","author":"Akaberi M.","year":"2021"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/phrev.phrev_13_17"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01021"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104392"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.11372"},{"key":"e_1_2_15_9_2","volume-title":"Exotic Superfoods Turmeric and Its Emerging Role in the American Food System","author":"Iyengar J.","year":"2019"},{"key":"e_1_2_15_10_2","volume-title":"Turmeric Unveiled: Exploring the Golden Spice\u2019s Health Benefits and Culinary Marvels","author":"Saras T.","year":"2023"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1040259"},{"key":"e_1_2_15_12_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103627","article-title":"Mechanistic Insights into the Beneficial Effects of Curcumin on Insulin Resistance: Opportunities and Challenges","volume":"28","author":"Balakumar P.","year":"2023","journal-title":"Drug Discovery Today"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7642"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/396708"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2018.09.002"},{"key":"e_1_2_15_16_2","first-page":"280","article-title":"A Review of Antioxidant Polyphenol Curcumin and Its Role in Detoxification","volume":"6","author":"Alrawaiq N. 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