{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:20Z","timestamp":1787840900360,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This prospective, observational study examined the efficacy of liraglutide in subjects with obesity who did not experience early weight loss during a behavioral intervention in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The weight loss intervention lasted for 12\u2009weeks, and at Week 6, we offered liraglutide to subjects who had lost less than 2.5% of their body weight (early unresponder (eUR)). Before and after the intervention, anthropometry, body composition, blood pressure, level of physical activity, nutrition knowledge, quality of life, and daytime sleepiness were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 174 participants, 78 subjects were classified as early unresponders: 21 (27%) agreed to start liraglutide therapy (eUR\u2010LT), and 57 declined (eUR\u2010NLT), primarily due to the out\u2010of\u2010pocket cost. Liraglutide was well tolerated. Four subjects complained of nausea and two of epigastralgia. During the 6\u201312\u2010week period, the weight loss was \u22123.5\u2009\u00b1\u20091.8\u2009kg (\u22123.2%) in the eUR\u2010LT group and \u22121.3\u2009\u00b1\u20091.6\u2009kg (\u22121.4%) in the eUR\u2010NLT,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001. Using liraglutide therapy, baseline body mass index, sex, age, and weight change at 6\u2009weeks as independent variables, the multivariate regression analysis found that only liraglutide therapy was significantly associated with weight loss from Week 6 to Week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). After 12\u2009weeks, total weight loss was \u22126.0\u2009\u00b1\u20092.4\u2009kg (\u22125.3%) in group eUR\u2010LT, \u22122.4\u2009\u00b1\u20091.9\u2009kg (\u22122.4%) in group eUR\u2010NLT, and \u22126.2\u2009\u00b1\u20092.3\u2009kg (\u22126.3%) in group eR. In the eUR\u2010LT group, 66.7% lost \u2265\u20095% of the initial weight; in group eUR\u2010NLT, 14%; and in group eR, 72.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Liraglutide therapy is beneficial for individuals with obesity who do not respond early to lifestyle intervention. However, the high cost of the drug remains a barrier to its use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jobe\/1224246","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:32:04Z","timestamp":1787837524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Liraglutide in Patients With Obesity Who Are Early Non\u2010Responders to Lifestyle Intervention: A Real\u2010World Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-0439","authenticated-orcid":false,"given":"Luisa","family":"Gilardini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verdiana","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-2607","authenticated-orcid":false,"given":"Marina","family":"Croci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7254-5988","authenticated-orcid":false,"given":"Silvia","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-8203","authenticated-orcid":false,"given":"Lucia","family":"Pasqualinotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Toja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-0500","authenticated-orcid":false,"given":"Luca","family":"Cavaggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-8074","authenticated-orcid":false,"given":"Simona","family":"Bertoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350627"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000492115"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2415"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000445504"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061382"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.23736\/s2724-6507.20.03212-5"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20777"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.5993\/ajhb.48.1.1"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibz149"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.162"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00351-9"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.329"},{"key":"e_1_2_10_14_2","first-page":"140","article-title":"Validazione Della Versione Italiana Del Questionario Di Moynihan Sulle Conoscenze Alimentari [Validation of the Italian Version of the Questionnaire on Nutrition Knowledge by Moynihan]","volume":"74","author":"da Vico L.","year":"2010","journal-title":"Monaldi Archives for Chest Disease"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_10_16_2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International Physical Activity Questionnaire: 12-Country Reliability and Validity","volume":"35","author":"Craig C. 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