{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T11:53:06Z","timestamp":1774180386140,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HR18C001208"],"award-info":[{"award-number":["HR18C001208"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS202300245081"],"award-info":[{"award-number":["RS202300245081"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare the molecular mechanisms and metabolic outcomes of Roux\u2010en\u2010Y gastric bypass (RYGB) and single anastomosis duodeno\u2013ileal bypass with sleeve gastrectomy (SADI\u2010S) using a preclinical model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Otsuka Long\u2010Evans Tokushima Fatty rats with diet\u2010induced obesity underwent RYGB, SADI\u2010S, or sham surgery. Metabolic parameters, including glucose tolerance, body weight, and 18F\u2010fluorodeoxyglucose biodistribution, were assessed at 1\u2010 and 2\u2010month postsurgery. The expression of Glucose transporter 1 (GLUT1) and glucose metabolism\u2013related genes in intestinal segments was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although RYGB and SADI\u2010S yielded comparable improvements in glucose tolerance and body weight at 1\u2009month postsurgery, they exerted their effects through distinct mechanisms. RYGB enhanced GLUT1\u2010mediated glucose excretion in the common limb, whereas SADI\u2010S upregulated the expression of the glycolytic genes\n                      <jats:italic>Hk2, Fbp2, Aldob,<\/jats:italic>\n                      and\n                      <jats:italic>Ldha<\/jats:italic>\n                      in the colon. Two months postsurgery, the observed metabolic improvements diminished despite sustained weight loss, which coincided with decreased expression of GLUT1 and glycolytic genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RYGB and SADI\u2010S achieve similar benefits through distinct glucose handling pathways; however, these effects decline over time. Our data do not support the superiority of SADI\u2010S over RYGB, particularly given its higher complication rate, and instead highlight the need for strategies aimed at prolonging the therapeutic benefits of metabolic surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jobe\/4870532","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:36:02Z","timestamp":1764347762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Roux\u2010en\u2010Y Gastric Bypass Versus Single Anastomosis Duodeno\u2013Ileal Bypass With Sleeve Gastrectomy: Different Mechanisms, Similar Outcomes"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6922-1418","authenticated-orcid":false,"given":"Hye 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