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The review protocol was registered in PROSPERO (CRD42023374612). PubMed, Embase, Scopus, Web of Science, SciELO, CINAHL, and LILACS were searched. Two independent reviewers selected studies, extracted data, and assessed methodological quality using the National Heart, Lung, and Blood Institute tool. Findings were synthesized narratively and through an exploratory random\u2010effects meta\u2010analysis of absolute SF\u201036 mean scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty cross\u2010sectional studies were included. The SF\u201036 and its variations were the most frequently used instruments. Across studies with BMI comparison groups, higher BMI categories were generally associated with lower QoL scores. The lowest scores were most consistently observed for physical functioning, role due to physical health, bodily pain, and general health. Among the mental health\u2010related domains, vitality showed the most consistently reduced scores. Between\u2010study heterogeneity was high for most pooled estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Across the available cross\u2010sectional evidence, adults with severe obesity generally had lower QoL, particularly in physical domains. However, substantial heterogeneity and the absence of longitudinal evidence limit certainty and preclude causal interpretation. Longitudinal studies using standardized QoL measures are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jobe\/6951531","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:40:06Z","timestamp":1792244406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life in Adults With Severe Obesity: A Systematic Review and Meta\u2010Analysis of Cross\u2010Sectional Studies"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-9149","authenticated-orcid":false,"given":"Tatiane Salgado Galv\u00e3o de","family":"Macedo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Food Nutrition and Health Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-1281","authenticated-orcid":false,"given":"Marina Magno do Nascimento","family":"Pereira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Food Nutrition and Health Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3723-4155","authenticated-orcid":false,"given":"Tham\u00edris do Amaral Roxo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Food Nutrition and Health Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8801-606X","authenticated-orcid":false,"given":"Ana Clara Rodrigues de","family":"Assump\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Food Nutrition and Health Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8476-8567","authenticated-orcid":false,"given":"Fl\u00e1via dos Santos Barbosa","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Social Nutrition Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-9567","authenticated-orcid":false,"given":"Cintia Chaves","family":"Curioni","sequence":"additional","affiliation":[{"name":"Department of Social Nutrition Institute of Nutrition State University of Rio de Janeiro  S\u00e3o Francisco Xavier Street, 524 Rio de Janeiro Rio de Janeiro Brazil  uerj.br"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002727-200304000-00011"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-020-00219-y"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12203"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311X00192518"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140"},{"key":"e_1_2_14_6_2","volume-title":"Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation","author":"World Health Organization","year":"2000"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30139-7"},{"key":"e_1_2_14_8_2","volume-title":"Obesity and Overweight","author":"Who","year":"2021"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"e_1_2_14_11_2","volume-title":"Qualidade de Vida: Defini\u00e7\u00e3o, Conceitos e Interfaces Com Outras \u00c1reas de Pesquisa. 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