{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:09:11Z","timestamp":1790604551830,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the independent and joint associations of the C\u2010reactive protein\u2013triglyceride\u2013glucose index (CTI) and the Chinese visceral adiposity index (CVAI) with incident stroke. Additionally, we evaluated whether a novel combined index, CTI\u2013CVAI, outperforms the established TyG\u2013CVAI in predicting stroke risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cohort study included 8267 stroke\u2010free participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox proportional hazards models, Kaplan\u2013Meier curves, and restricted cubic splines were utilized to analyze associations with incident stroke. Additive and multiplicative interactions between CTI and CVAI were examined. Predictive performance was assessed via receiver operating characteristic (ROC) analysis, comparing CTI\u2013CVAI against TyG\u2013CVAI using DeLong\u2019s test and the Boruta algorithm for feature importance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 8.37\u2009years, 816 incident stroke cases were identified. Elevated CTI and CVAI were independently associated with increased stroke risk in a linear dose\u2013response manner, without significant interaction. The novel CTI\u2013CVAI index exhibited a robust association with stroke; participants in the highest tertile had a 2.14\u2010fold higher risk (HR 2.14, 95% CI 1.75\u20132.62) compared to the lowest. Crucially, CTI\u2013CVAI demonstrated superior predictive accuracy (AUC 0.627) over the established TyG\u2013CVAI index (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), a finding supported by consistent results across subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CTI and CVAI are independent risk factors for stroke, and their combination (CTI\u2013CVAI) offers enhanced predictive value, outperforming the TyG\u2013CVAI index. Monitoring CTI\u2013CVAI may serve as a superior strategy for early risk stratification and targeted stroke prevention in middle\u2010aged and elderly populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jobe\/8894079","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:28:28Z","timestamp":1790602108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint Association of Inflammatory\u2010Metabolic Indices With Risk of Incident Stroke Among Middle\u2010Aged and Older Chinese Adults"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-1153","authenticated-orcid":false,"given":"Binbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-792X","authenticated-orcid":false,"given":"Gangzhen","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211065917"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0310-2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031063"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01479-9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01394-4"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02313-z"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039542"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70422"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01870-z"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02122-4"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02668-x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02854-x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.905266"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02835-0"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02945-9"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1201132"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02724-6"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i11"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02686-9"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02960-w"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02848-9"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02876-5"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0099"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02770-0"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01095-4"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70109"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04309-x"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-24094-5"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-024-00332-8"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.01.006"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110691"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112408"}],"container-title":["Journal 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