{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:59:24Z","timestamp":1791323964337,"version":"4.3.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orlistat is a potent lipase inhibitor utilized as a preventive agent for obesity and fat absorption control. Existing literature presents conflicting findings regarding its impact on lipid parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review followed the PRISMA guidelines and was registered in PROSPERO (ID: CRD42024550889). A comprehensive search of PubMed, Scopus, Web of Science, and Cochrane Register of Controlled Trials was conducted for studies published before January 19, 2025. Eligible studies included randomized controlled trials (RCTs) evaluating orlistat in adults (\u2265\u200918\u2009years) with dyslipidemia. Furthermore, the Grading of Recommendations, Assessment, Development, and Evaluations assessment tool was employed to analyze the certainty of evidence or each outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total number of 1369 participants, with 682 in treatment and 687 in control categories, were included in our study. Orlistat reduced body mass index (BMI) (SMD [95% CI]: \u22120.30 [\u20100.58, \u22120.03],\n                      <jats:italic>p<\/jats:italic>\n                      value (heterogeneity)\u2009=\u20090.026), and also it was associated with a decrease in high\u2010density lipoprotein cholesterol (SMD (95% CI): \u22120.31 [\u20100.48, \u22120.13],\n                      <jats:italic>p<\/jats:italic>\n                      value (heterogeneity)\u2009=\u20090.436). Changes in waist circumference (WC) and triglycerides (TGs) did not reach statistical significance in the primary analysis (WC: SMD [95% CI] \u22120.1562 [\u20100.3138; 0.0015],\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value (heterogeneity)\u2009=\u20090.7572; TG: SMD [95% CI] \u22120.1668 [\u20100.7979; 0.4642],\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200997.7%\n                      <jats:italic>p<\/jats:italic>\n                      value (heterogeneity)\u2009&lt;\u20090.0001); however, after publication\u2010bias adjustment using the trim\u2010and\u2010fill sensitivity analysis, meaningful reductions were discovered for WC (SMD (%95CI): \u22120.1712 [\u20100.3248; \u22120.0176],\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%,\n                      <jats:italic>p<\/jats:italic>\n                      value (heterogeneity)\u2009=\u20090.7696) and TG (SMD (%95CI): \u22120.8900 [\u20101.6619; \u22120.1181],\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200997.9%,\n                      <jats:italic>p<\/jats:italic>\n                      value (heterogeneity)\u2009&lt;\u20090.0001). The secondary analysis demonstrated that follow\u2010up duration accounted for 30% of TG heterogeneity, suggesting a small but significant decline in orlistat\u2019s TG\u2010lowering effect over time (slope: \u22120.1239; 95% CI: \u22120.2355, \u22120.0123;\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.0295). No significant changes were observed in other parameters of the study. Besides, gastrointestinal issues were the most frequently reported adverse events among the studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that orlistat meaningfully reduces BMI but is associated with decreased HDL\u2010C, which may be undesirable given HDL\u2010C\u2019s protective role in cardiovascular health. Evidence for reductions in TG and WC is uncertain: the primary meta\u2010analysis showed no statistically significant effects, whereas trim\u2010and\u2010fill sensitivity analysis suggested potential reductions. No significant short\u2010term impact on TG was observed, though a modest reduction may emerge with prolonged use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/jobe\/9068305","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:39:36Z","timestamp":1772991576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Effects of Orlistat on Lipid Metabolism and Anthropometric Indices: A Meta\u2010Analysis of Clinical 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