{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T17:06:42Z","timestamp":1779728802417,"version":"3.53.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At our institution, 99mTc\u2010MAG3 renal scintigraphy is routinely performed preoperatively in living kidney donors and on postoperative Day 1 in recipients. Given the interindividual variability in MAG3 clearance, we hypothesized that postoperative MAG3 clearance could serve as an early indicator of renal graft function. In addition, we explored whether the donor\u2010to\u2010recipient clearance ratio (M\u2010ratio) provides supplemental clinical value. Early identification of such indicators of graft function is essential for optimizing postoperative management and improving outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed 52 living donor kidney transplants performed between October 2009 and May 2024. Associations were examined between donor and recipient MAG3 clearance values, the M\u2010ratio (elevated \u2265 1.5 vs decreased\/stable &lt; 1.5), donor\/recipient age and sex, T1\/2 pattern (good excretion \u2264 20\u2009min vs delayed &gt; 20\u2009min or unmeasurable), total ischemic time, graft weight, dialysis duration, and estimated glomerular filtration rate (eGFR) at 1\u2009week and 1\u201312\u2009months postoperatively. Variables with\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 in univariate analysis entered multivariate regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Univariate analysis showed that recipient MAG3 clearance, the M\u2010ratio, donor and recipient age, T1\/2 (up to 1\u2009month), and graft weight (at 1\u2009week) were significantly associated with graft function. In contrast, donor MAG3 clearance was not correlated with postoperative renal function. In multivariate analysis, recipient MAG3 clearance, recipient age, and graft weight remained independently associated with early graft function, whereas the M\u2010ratio lost significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recipient MAG3 clearance on postoperative Day 1 is a practical, noninvasive indicator of renal graft function, while donor clearance and the M\u2010ratio are not independently associated with postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joot\/4619384","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:59:56Z","timestamp":1779728396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Utility of Postoperative Day 1 Technetium\u201099m Mercaptoacetyltriglycine Scintigraphy for Early Assessment of Graft Function in Living Donor Kidney Transplant Recipients"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8938-9824","authenticated-orcid":false,"given":"Shun","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-4524","authenticated-orcid":false,"given":"Yoshitaka","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Onose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Maeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiro","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4757-4633","authenticated-orcid":false,"given":"Akira","family":"Ohtsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-2394","authenticated-orcid":false,"given":"Yoshiyuki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-735X","authenticated-orcid":false,"given":"Seiji","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Hatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_13_1_2","first-page":"346","article-title":"Dynamic Renal Scintigraphy (99mTc-DTPA, 99mTc-MAG3), Static Renal Scintigraphy (99mTc-DTPA), and Urinary Tract Scintigraphy","volume":"78","author":"Ishii S.","year":"2024","journal-title":"Rinsho Hinyokika"},{"key":"e_1_2_13_2_2","first-page":"689","article-title":"Comparison of Single-Sample Methods for Measuring 99mTc-MAG3 Plasma Clearance","volume":"35","author":"Ito K.","year":"1998","journal-title":"Kaku Igaku"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199006000-00001"},{"key":"e_1_2_13_4_2","first-page":"757","article-title":"A Simple Method for Measuring Effective Renal Plasma Flow Using 99mTc-MAG3 Gamma Camera Renography Based on a One-Compartment Model","volume":"55","author":"Oriuchi N.","year":"1995","journal-title":"Nippon Hoshasen Gijutsu Gakkai Zasshi"},{"key":"e_1_2_13_5_2","first-page":"1955","article-title":"Estimation of Technetium-99m-MAG3 Plasma Clearance in Adults From One or Two Blood Samples","volume":"30","author":"Russell C. 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