{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:58:49Z","timestamp":1777903129877,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To retrospectively review all cases of posttransplant lymphoproliferative disorder (PTLD) in a large Brazilian transplant center, describing patients\u2019 clinical, virological, and histopathological profiles and treatment strategies and prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted between January 2000 and June 2024. Adult patients with confirmed PTLD following solid\u2010organ or bone marrow transplant were included. Patients with other systemic cancers or on concurrent chemotherapy\/radiotherapy were excluded. Clinical characteristics, PTLD prevalence, histopathology, and survival were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010eight cases of PTLD were identified in the 5928 transplant patients (0.6%). Incidence was highest in lung recipients (31%). Median time to PTLD onset was 42\u2009months. EBV DNA was detectable in 54.8% of cases. Monomorphic PTLD was the most common (89.5%), primarily in non\u2010Hodgkin lymphomas (91.2%). Immunotherapy (anti\u2010CD20) and immunosuppression reduction were standard initial treatments. R\u2010CHOP and rituximab monotherapy were the main first\u2010line regimens. Age and treatment response significantly influenced overall survival. Mortality was 42%, mainly due to infections and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the higher prevalence of EBV in Brazil, PTLD patterns and incidence were consistent with those found in developed countries. The strong association with lung transplants mirrors global data. Local EBV subtype characteristics and host immunogenetic factors warrant further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joot\/6468943","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:42:49Z","timestamp":1766990569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posttransplant Lymphoproliferative Disorder (PTLD): 24\u2009Years of Experience at a Referral Center in S\u00e3o Paulo, Brazil. Can Differences in Prevalence and Subtype of EBV Infection in the Population Influence the Results? A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-2032","authenticated-orcid":false,"given":"Juliano C\u00f3rdova","family":"Vargas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Helman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Marcelino de Souza","family":"Dur\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Ferraz de","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jos\u00e9 Eduardo","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Medeiros","family":"Carraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Amorim","family":"Curvelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Eduardo Gon\u00e7alves","family":"Felga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Eduardo Louren\u00e7o","family":"Matielo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Holanda","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Pasqualin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Stanzione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Perini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-681411"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000003549"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.37282"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14081762"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2023.09.007"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr076"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25547"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)61050-2"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601219"},{"key":"e_1_2_10_10_2","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S. 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