{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:55:46Z","timestamp":1791006946451,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":274,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracoabdominal normothermic regional perfusion (TA\u2010NRP) and hypothermic machine perfusion (HMP) reduce ischemia\u2013reperfusion injury after donation after circulatory death (DCD) kidney transplantation, but their combined effects remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult DCD kidney\u2010only recipients undergoing pretransplant dialysis in the OPTN registry (2020\u20132025) were stratified by TA\u2010NRP and HMP. The primary outcome was delayed graft function (DGF). Multivariable logistic regression included a TA\u2010NRP\u2009\u00d7\u2009HMP interaction and adjusted for recipient and donor factors. Death\u2010censored graft survival (DCGS) was evaluated by Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3502 recipients, DGF differed by preservation strategy. In the non\u2010TA\u2010NRP cohort, HMP significantly reduced DGF compared with static cold storage (SCS) (44.2% vs 53.8%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and remained independently protective (adjusted OR 0.56; 95% CI 0.44\u20130.71;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). In the TA\u2010NRP cohort, DGF rates were similar between HMP and SCS (26.7% vs 27.0%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.98), with no independent association after adjustment (adjusted OR 0.82; 95% CI 0.62\u20131.08;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.16). A significant TA\u2010NRP\u2009\u00d7\u2009HMP interaction was observed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039). In the absence of HMP, TA\u2010NRP was strongly protective against DGF (adjusted OR 0.30; 95% CI 0.22\u20130.42;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). At 3\u2009years, DCGS was 93.9% (95% CI 91.5\u201396.4) for TA\u2010NRP\u2010HMP, 94.3% (90.9\u201397.9) for TA\u2010NRP\u2010SCS, 93.5% (91.5\u201395.6) for non\u2010TA\u2010NRP\u2010HMP, and 92.7% (89.1\u201396.6) for non\u2010TA\u2010NRP\u2010SCS, with no difference between groups (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.73).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TA\u2010NRP was associated with lower DGF than conventional DCD procurement. Within the TA\u2010NRP cohort, HMP was not associated with additional reductions in DGF. These findings should be interpreted in light of the surrogate definition used to identify TA\u2010NRP in the OPTN registry and warrant prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joot\/8082011","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:48:47Z","timestamp":1791006527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thoracoabdominal Normothermic Regional Perfusion Attenuates the Protective Effect of Hypothermic Machine Perfusion on Delayed Graft Function in DCD Kidney Transplantation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0068-1090","authenticated-orcid":false,"given":"Ayham","family":"Asassfeh","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8266-3823","authenticated-orcid":false,"given":"Enida","family":"Luma","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-4307","authenticated-orcid":false,"given":"Matthew","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-2398","authenticated-orcid":false,"given":"Emre","family":"Arpali","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-0659","authenticated-orcid":false,"given":"Ty B.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-9638","authenticated-orcid":false,"given":"Matthew","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-4654","authenticated-orcid":false,"given":"Badi","family":"Rawashdeh","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical College of Wisconsin  Milwaukee Wisconsin USA  mcw.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70442"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106021"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2022.02.062"},{"key":"e_1_2_9_4_2","article-title":"Impact of Delayed Graft Function on Allograft Survival in DCD Versus DBD Kidneys","volume":"19","author":"Ishaque T.","year":"2019","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_9_5_2","article-title":"Delayed Graft Function and Long-Term Graft Survival in Dbd and Dcd Kidney Recipients","volume":"30","author":"Massie A.","year":"2017","journal-title":"Transplant International"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000542290"},{"key":"e_1_2_9_7_2","doi-asserted-by":"crossref","DOI":"10.1097\/MOT.0000000000001275","article-title":"Normothermic Machine Perfusion Applications in Kidney Transplantation","author":"Holzner M. 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