{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:26:02Z","timestamp":1789694762647,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary tract infections (UTIs) remain the leading infectious complication after kidney transplantation. We evaluated intraoperative gentamicin bladder irrigation as a novel preventive strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, double\u2010blind controlled trial at a tertiary transplant center (January\u2010December 2021), 147 kidney transplant recipients were randomized to receive intraoperative bladder irrigation with gentamicin (160\u2009mg\/250\u2009mL) or saline during ureteroneocystostomy. Due to baseline imbalances, propensity score matching yielded 49 matched pairs. The primary endpoint was UTI incidence within 30\u2009days post\u2010transplant, defined by both microbiological (\u2265\u200910\n                      <jats:sup>5<\/jats:sup>\n                      \u2009CFU\/mL) and clinical criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      UTI incidence was 26.5% (13\/49) in controls versus 16.3% (8\/49) with gentamicin (absolute risk reduction 10.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.325). The number needed to treat was 10 overall. Striking sex\u2010specific differences emerged: females demonstrated 40.7% baseline UTI risk versus 14.1% in males (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Gentamicin efficacy varied markedly by sex, with the NNT of 5 for females (50.0%\u201330.8%) versus 17 for males (17.1%\u201311.1%). Living donor recipients showed greater benefit (NNT\u2009=\u20097) than deceased donor recipients (NNT\u2009=\u200923). No adverse events were attributable to gentamicin, with similar rates of bacteremia and surgical site infections between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative gentamicin bladder irrigation safely reduced early post\u2010transplant UTIs by 38.5%, with efficacy in female recipients. While underpowered for statistical significance, the clinically meaningful effect size and excellent safety profile support considering this intervention for high\u2010risk recipients, especially females, pending larger confirmatory trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joot\/9377493","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T04:47:03Z","timestamp":1764478023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Intraoperative Gentamicin Bladder Irrigation for Mitigation of Urinary Tract Infections After Kidney Transplantation: A Propensity Score\u2013Matched Analysis of a Randomized Controlled Trial"],"prefix":"10.1155","volume":"2025","author":[{"given":"Aviad","family":"Gravetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Tennak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mais","family":"Khamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadym","family":"Mezhybovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gurevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigal","family":"Eisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasnim","family":"Lubani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-0032","authenticated-orcid":false,"given":"Dana","family":"Bielopolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Atamna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9754-5028","authenticated-orcid":false,"given":"Fahim","family":"Kanani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eviatar","family":"Nesher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042307-200203000-00007"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00327.x"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.02014.x"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-019-00585-3"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.04.222"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.065"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00519.x"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01700.x"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx237"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00323.x"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12695"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12759"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.02.002"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13075"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251036"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.12659\/aot.883901"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-1248"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12547"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.4434"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000296303"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02834.x"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13507"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00644.x"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.UTI-0025-2016"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(05)00928-6"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.11.006"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1990.tb01878.x"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00104.x"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa060068"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2012.0093"},{"key":"e_1_2_15_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011455.pub2"},{"key":"e_1_2_15_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2010.05.001"},{"key":"e_1_2_15_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13467-w"}],"container-title":["Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/joot\/9377493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/joot\/9377493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/joot\/9377493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:50:21Z","timestamp":1777636221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/joot\/9377493"}},"subtitle":[],"editor":[{"given":"Reut","family":"Hod-Dvorai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/joot\/9377493"],"URL":"https:\/\/doi.org\/10.1155\/joot\/9377493","archive":["Portico"],"relation":{},"ISSN":["2090-0007","2090-0015"],"issn-type":[{"value":"2090-0007","type":"print"},{"value":"2090-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9377493"}}