{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:59:07Z","timestamp":1782215947546,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":173,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201174"],"award-info":[{"award-number":["82201174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7232025"],"award-info":[{"award-number":["7232025"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Bureau of Health","doi-asserted-by":"publisher","award":["QML20230203"],"award-info":[{"award-number":["QML20230203"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To quantify interleukin\u201036 receptor antagonist (IL\u201036Ra), interleukin\u201037 (IL\u201037), and interleukin\u201038 (IL\u201038) levels in aqueous humor and plasma of patients with primary glaucoma, and investigate their correlations with glaucomatous structural damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Matched aqueous humor and plasma samples were collected from patients with acute primary angle\u2010closure glaucoma (APACG), chronic PACG (CPACG), and primary open\u2010angle glaucoma (POAG), and age\u2010related cataract controls (ARC). Levels of IL\u201036Ra, IL\u201037, and IL\u201038 were quantified and correlated with average retinal nerve fiber layer thickness (RNFLT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 96 participants were enrolled, including 25 APACG, 23 CPACG, 23 POAG, and 25 ARC. In aqueous humor, IL\u201036Ra was significantly elevated in CPACG compared to all other groups, while IL\u201037 and IL\u201038 were markedly increased in both CPACG and POAG compared to ARC and APACG (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In plasma, IL\u201036Ra was significantly lower in the POAG and APACG than in ARC and CPACG, and IL\u201038 was reduced in APACG compared to all other groups (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). All three cytokines in aqueous humor, as well as plasma IL\u201036Ra and IL\u201038, showed significant negative correlations with average RNFLT. Notably, aqueous humor IL\u201038 exhibited the strongest association with RNFLT, particularly within the POAG (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.745,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and CPACG (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.496,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016) subgroups, suggesting an association with structural damage in chronic glaucoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aqueous humor IL\u201038 levels correlated with RNFLT thinning in POAG and CPACG, suggesting a potential role as a biomarker associated with structural damage. IL\u201036Ra was independently elevated in CPACG, supporting its potential as a subtype\u2010related biomarker. Further studies are needed to clarify the mechanisms of these cytokines in glaucoma pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/1806762","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:34:13Z","timestamp":1782214453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Cytokine Signatures in Primary Glaucoma Subtypes: Diagnostic and Pathophysiological Insights From IL\u201036Ra, IL\u201037, and IL\u201038"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-6864","authenticated-orcid":false,"given":"Yawen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-5389","authenticated-orcid":false,"given":"Xiaowei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-7831","authenticated-orcid":false,"given":"Yulei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuitang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-3263","authenticated-orcid":false,"given":"Hengli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1516-7044","authenticated-orcid":false,"given":"Yizhen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_14_2_2","first-page":"83","article-title":"Models of Open-Angle Glaucoma Prevalence and Incidence in the United States","volume":"38","author":"Quigley H. 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