{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:48:20Z","timestamp":1782870500046,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":180,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Postoperative endophthalmitis remains a vision\u2010threatening complication despite advances in treatment. Current prognostic markers (Gram stain and initial visual acuity) have limited predictive values for real\u2010time retinal neuronal function assessment and visual recovery. The purpose of this pilot study was to explore whether photopic electroretinograms might be used to forecast the endophthalmitis prognosis following intravitreal injection or phacoemulsification intraocular lens implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects\/Methods<\/jats:title>\n                    <jats:p>This prospective observational study included 11 consecutive patients with acute postoperative endophthalmitis following phacoemulsification with IOL implantation (3 eyes) or intravitreal injections (8 eyes). ERGs were recorded using a portable RETeval\u2122 system under nonmydriatic conditions. R Core Team (2019) was used to assess the preoperative electroretinogram outcomes, duration until the onset of endophthalmitis, procedure types of original surgeries, and pre\u2010 and postoperative best\u2010corrected visual acuity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean patient age was 79.23\u2009years (range 62\u201388). A significant correlation was found between interocular photopic flicker latency difference and BCVA improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04, &lt; 0.05). Patients with \u2264 8\u2009ms latency difference showed significantly better visual recovery (\u2265 2\u2010line gain). No significant correlations were found with diabetes status, original surgical procedure types, or time to symptom onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this hypothesis\u2010generating pilot study of acute postoperative endophthalmitis, a smaller interocular flicker ERG latency difference at presentation is associated with better visual recovery. These preliminary findings suggest that this rapid, noninvasive functional test may have potential as a prognostic biomarker and warrants further validation in larger cohorts, complementing existing clinical and microbiological parameters in the management of this sight\u2010threatening infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/2982435","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:24:13Z","timestamp":1782869053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Interocular Flicker ERG Asymmetry in Acute Postoperative Endophthalmitis After Intraocular Surgery: A Pilot Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-0199","authenticated-orcid":false,"given":"Ying","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Dulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-4480","authenticated-orcid":false,"given":"Vasyl","family":"Druchkiv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Stephan","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-3228","authenticated-orcid":false,"given":"Christos","family":"Skevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00347-020-01271-7","article-title":"Postoperative Endophthalmitis-A Review of Literature","volume":"118","author":"Bisorca-Gassendorf L.","year":"2021","journal-title":"Der Ophthalmologe"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2022.02.20"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120902028"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278625"},{"key":"e_1_2_11_5_2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0002-9394(14)70380-0","article-title":"Microbiologic Factors and Visual Outcome in the Endophthalmitis Vitrectomy Study","volume":"122","author":"Endophthalmitis Vitrectomy Study Group","year":"1996","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_11_6_2","first-page":"1758","article-title":"Pseudomonas Endophthalmitis in Rabbits: Intravitreal Inoculation of Two Pseudomonas Strains","volume":"92","author":"Hatano H.","year":"1988","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_11_7_2","first-page":"1650","article-title":"A Hemolysin Encoding Plasmid Contributes to Bacterial Virulence in Experimental Enterococcus faecalis Endophthalmitis","volume":"33","author":"Stevens S. 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