{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:44:32Z","timestamp":1791787472684,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":283,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the agreement between preoperative optical coherence tomography (OCT)\u2013derived central corneal epithelial thickness (CET) and an intraoperative epithelial thickness estimate derived from optical coherence pachymetry (OCP) during alcohol\u2010assisted photorefractive keratectomy (PRK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on 116 eyes of 58 consecutive patients who underwent bilateral myopic alcohol\u2010assisted PRK between June 2020 and October 2021. Preoperative CET was assessed using anterior\u2010segment OCT. The OCP\u2010derived intraoperative epithelial thickness estimate was calculated as the difference between total corneal pachymetry readings obtained immediately before and after epithelial removal. Demographic, preoperative clinical, and refractive data, as well as intraoperative laser parameters, were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 26.31\u2009\u00b1\u20097.44\u2009years (range, 18\u201345), and 63.8% of patients were female. Mean sphere and spherical equivalent were \u22123.49\u2009\u00b1\u20091.63D and \u22123.16\u2009\u00b1\u20091.63D, respectively. Mean preoperative OCT\u2010derived CET was 53.2\u2009\u00b1\u20093.5\u2009\u2009\u03bcm (range, 42\u201369\u2009\u2009\u03bcm), whereas the mean OCP\u2010derived intraoperative CET was significantly higher at 59.8\u2009\u00b1\u200914.8\u2009\u2009\u03bcm (range, 21\u201399\u2009\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). This discrepancy was consistent in both eyes of each patient. The intraoperative estimate exceeded the preoperative OCT\u2010derived CET in 73.3% of eyes. Bland\u2013Altman analysis demonstrated poor agreement between the two approaches, with wide limits of agreement from \u221215.7\u2009\u2009\u03bcm to +34.8\u2009\u2009\u03bcm. Preoperatively, 98.3% of eyes had CET values within the 40\u201360\u2010\u03bcm range, compared with 44.8% of the OCP\u2010derived intraoperative estimates. The difference between measurements significantly correlated with preoperative corneal thickness (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and intraoperative CET (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) but not refractive error or intraoperative and environmental parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative OCT\u2010derived CET and OCP\u2010derived intraoperative CET demonstrate a systematic discrepancy and poor agreement during alcohol\u2010assisted PRK. The intraoperative estimates were higher on average and substantially more variable than preoperative OCT measurements. These differences may have implications for surface ablation procedures, particularly transepithelial PRK, in which an assumed epithelial thickness profile is incorporated into treatment planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/joph\/4117242","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:44:38Z","timestamp":1791783878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discrepancy Between Preoperative and Intraoperative Central Corneal Epithelial Thickness During Alcohol\u2010Assisted PRK"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-5378","authenticated-orcid":false,"given":"Dana","family":"Barequet","sequence":"first","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Medical Center  Tel Aviv Israel  tau.ac.il"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-0225","authenticated-orcid":false,"given":"Nadav","family":"Levinger","sequence":"additional","affiliation":[{"name":"Enaim Refractive Surgery Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4870-7905","authenticated-orcid":false,"given":"Oren","family":"Golan","sequence":"additional","affiliation":[{"name":"Enaim Refractive Surgery Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-9649","authenticated-orcid":false,"given":"Samuel","family":"Levinger","sequence":"additional","affiliation":[{"name":"Enaim Refractive Surgery Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-0226","authenticated-orcid":false,"given":"Irina","family":"Barequet","sequence":"additional","affiliation":[{"name":"Enaim Refractive Surgery Center  Tel Aviv Israel"},{"name":"Goldschleger Eye Institute Sheba Medical Center  Tel Hashomer Israel  sheba.co.il"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31314-5"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19930101-10"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.05.010"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008314"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-016-0457-x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000850"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0039-6"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2964"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000417"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.025"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2019.04.019"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000170694.90455.f7"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.3.214.15412"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597x-20060501-11"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.06.023"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.04.068"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0447-7"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3867-7"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000422"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200305000-00005"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000714"},{"key":"e_1_2_9_22_2","first-page":"995","article-title":"Confocal Microscopy in Vivo in Corneas of Long-Term Contact Lens Wearers","volume":"43","author":"Patel S. 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