{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:09:19Z","timestamp":1792606159404,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":363,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background<\/jats:title>\n To evaluate visual acuity outcome after excimer laser phototherapeutic keratectomy (PTK) for epithelial basement membrane dystrophy (EBMD) and to provide new insights into higher\u2010order aberrations (HOAs) and corneal density changes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this single\u2010center cohort, 92 eyes from 80 individuals underwent PTK for EBMD, with follow\u2010up durations reaching up to 7.5 years (mean 332\u2009\u00b1\u2009526.5 days).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean BCVA in EBMD improved by 0.17\u2009\u00b1\u20090.17 logMAR (\n p<\/jats:italic>\n < 0.001) for patients without visual acuity limitations and by 0.14\u2009\u00b1\u20090.31 (\n p<\/jats:italic>\n = 0.004) logMAR if patients had additional visual acuity limitations. Refraction remained stable after PTK. HOA reduced by 0.16\u2009\u00b1\u20090.23\u2009\u03bcm (\n p<\/jats:italic>\n < 0.001), corneal density by 6.73\u2009\u00b1\u200911.83\u2009gray scale units (\n p<\/jats:italic>\n < 0.001), and\n K<\/jats:italic>\n max<\/jats:sub>\n by 1.02 dpt (\u00b12.73) (\n p<\/jats:italic>\n = 0.006) after PTK. A correlation before and after PTK between HOA (\n p<\/jats:italic>\n = 0.014 and 0.002), corneal density (\n p<\/jats:italic>\n < 0.002), and\n K<\/jats:italic>\n max<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.010) with BCVA was observed. Light haze occurred in 10% of the cases. Re\u2010PTK was necessary for 1 patient (1.1%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n PTK significantly enhances visual acuity in patients with EBMD, independently of additional visual acuity limitations. The significant reduction of HOA, corneal density, and\n K<\/jats:italic>\n max<\/jats:sub>\n as well as the correlation of these parameters with visual acuity prove an effective therapy on an objective level.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/joph\/4801704","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:19:50Z","timestamp":1767165590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher\u2010Order Aberrations, Corneal Density, and Visual Acuity After Excimer Laser Phototherapeutic Keratectomy (PTK) for Epithelial Basement Membrane Dystrophy"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-5922","authenticated-orcid":false,"given":"Simon","family":"Helm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0496-4921","authenticated-orcid":false,"given":"Johanna","family":"Wiedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-8667","authenticated-orcid":false,"given":"Benjamin","family":"Rosswinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-7609","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1958-411X","authenticated-orcid":false,"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-6434","authenticated-orcid":false,"given":"Simona","family":"Schlereth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"2283","article-title":"Structure 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